• The Browse option provides the full collection of curated entries presented in an interactive table.
    • Each row corresponds to one signaling event and includes the following fields: Organism (exact species), Stress, Signal source, Signal molecules, Signal types, Receptor, Process (signaling pathway), Function (regulation, etc) and Reference. The Reference column lists the first author and publication year, along with the DOI and the clickable URL (PubMed).
    • Users can browse all the data entries, sort the table by any column, apply text filters that support multi-column combination filtering, and download the results view as CSV files.
Mitocommun_id Organism Stress Source Signal Type Receptor Process Function Reference URL
MC001 Homo sapiens \ Mito. membrane, Phospholipid synthesis Choline Metabolite Neuronal acetylcholine receptor subunit alpha-4 \ Neuromodulation Eaton et al. (2003). DOI: 10.1124/mol.64.6.1283 https://www.ncbi.nlm.nih.gov/pubmed/14645658
MC002 Rattus norvegicus \ Mito. membrane, Phospholipid synthesis Choline Metabolite Neuronal acetylcholine receptor subunit alpha-4 \ Neuromodulation Xiao et al. (2004). DOI: 10.1124/jpet.104.066787 https://www.ncbi.nlm.nih.gov/pubmed/15016836
MC003 Rattus norvegicus \ Mito Methionine metabolism SAM(S-Adenosylmethionine) Metabolite Adenosine receptor A1 cAMP-PKA-CREB(Inhibition) Purinergic-Methylation Pathway Crosstalk van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC004 Rattus norvegicus \ Mito Methionine metabolism SAM(S-Adenosylmethionine) Metabolite Adenosine receptor A2a cAMP-PKA-CREB(Activation) Purinergic-Methylation Pathway Crosstalk van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC005 Caenorhabditis elegans \ Mito Methionine metabolism SAM(S-Adenosylmethionine) Metabolite Phosphoethanolamine N-methyltransferase 1 \ Phospholipid Biosynthesis (Membrane Homeostasis / Epigenetic Precursor) Lee et al. (2011). DOI: 10.1074/jbc.M111.290619 https://www.ncbi.nlm.nih.gov/pubmed/21914812
MC006 Homo sapiens \ Mito. Matrix (OXPHOS) ATP(Adenosine triphosphate) Metabolite Heat shock 70 kDa protein 1A \ Proteostasis Maintenance Williamson et al. (2009). DOI: 10.1021/jm801627a https://www.ncbi.nlm.nih.gov/pubmed/19256508
MC007 Homo sapiens \ Mito. Matrix (OXPHOS) ATP(Adenosine triphosphate) Metabolite Heat shock cognate 71 kDa protein \ Proteostasis Maintenance Sanford-Burnham Center for Chemical Genomics. (2008). PubChem AID: 1193 https://pubchem.ncbi.nlm.nih.gov/bioassay/1193
MC008 Homo sapiens \ Mito. Matrix (OXPHOS) ATP(Adenosine triphosphate) Metabolite P2X purinoceptor 2 NLRP3 inflammasome Pro-inflammatory Signaling/Pyroptosis (Cell Death, Inflammation) Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC009 Homo sapiens \ Mito. Matrix (OXPHOS) ATP(Adenosine triphosphate) Metabolite P2X purinoceptor 3 \ Inflammation Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC010 Rattus norvegicus \ Mito. Matrix, One-carbon metabolism Glycine SmallMolecule 5-hydroxytryptamine receptor 7 \ Neuromodulation Greenberg et al. (1976). DOI: 10.1016/0024-3205(76)90375-1 https://www.ncbi.nlm.nih.gov/pubmed/7724
MC011 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Hematopoietic prostaglandin D synthase \ Neuro-Immune Homeostatic Regulation Abramovitz et al. (2000). DOI: 10.1016/s1388-1981(99)00164-x https://www.ncbi.nlm.nih.gov/pubmed/10634944
MC012 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostacyclin receptor \ Systemic Homeostasis Blair et al. (1981). DOI: 10.1111/j.1476-5381.1981.tb10994.x https://www.ncbi.nlm.nih.gov/pubmed/6266565
MC013 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostacyclin receptor \ Systemic Homeostasis MacDermot et al. (1981). DOI: 10.1016/0006-2952(81)90220-3 https://www.ncbi.nlm.nih.gov/pubmed/6271132
MC014 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP1 subtype \ Inflammation Kiriyama et al. (1997). DOI: 10.1038/sj.bjp.0701367 https://www.ncbi.nlm.nih.gov/pubmed/9313928
MC015 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP2 subtype \ Physiological Response Programs Abramovitz et al. (2000). DOI: 10.1016/s1388-1981(99)00164-x https://www.ncbi.nlm.nih.gov/pubmed/10634944
MC016 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP2 subtype \ Physiological Response Programs Kiriyama et al. (1997). DOI: 10.1038/sj.bjp.0701367 https://www.ncbi.nlm.nih.gov/pubmed/9313928
MC017 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP3 subtype \ Physiological Response Programs Kiriyama et al. (1997). DOI: 10.1038/sj.bjp.0701367 https://www.ncbi.nlm.nih.gov/pubmed/9313928
MC018 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP4 subtype \ Anti-inflammatory, Angiogenesis, Tissue Repair Abramovitz et al. (2000). DOI: 10.1016/s1388-1981(99)00164-x https://www.ncbi.nlm.nih.gov/pubmed/10634944
MC019 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin E2 receptor EP4 subtype \ Anti-inflammatory, Angiogenesis, Tissue Repair Kiriyama et al. (1997). DOI: 10.1038/sj.bjp.0701367 https://www.ncbi.nlm.nih.gov/pubmed/9313928
MC020 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Prostaglandin F2-alpha receptor \ Physiological Response Programs Kiriyama et al. (1997). DOI: 10.1038/sj.bjp.0701367 https://www.ncbi.nlm.nih.gov/pubmed/9313928
MC021 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Solute carrier organic anion transporter family member 2A1 \ Termination of Prostaglandin Signaling Abramovitz et al. (2000). DOI: 10.1016/s1388-1981(99)00164-x https://www.ncbi.nlm.nih.gov/pubmed/10634944
MC022 Mus musculus \ Mito, Energy/Precursor supply Prostaglandin E2 Lipid.Eicosanoid Thromboxane A2 receptor \ Systemic Homeostasis Armstrong et al. (1983). DOI: 10.1111/j.1476-5381.1983.tb10541.x https://www.ncbi.nlm.nih.gov/pubmed/6317122
MC023 Homo sapiens \ Mito, NADPH supply 20-Hydroxy-leukotriene B4 Lipid.Eicosanoid Leukotriene B4 receptor 1 \ Inflammation/Immunity Wang et al. (2000). DOI: 10.1074/jbc.M004512200 https://www.ncbi.nlm.nih.gov/pubmed/11006272
MC024 Homo sapiens \ Mito, NADPH supply 20-Hydroxy-leukotriene B4 Lipid.Eicosanoid Leukotriene B4 receptor 2 \ Inflammation/Immunity Wang et al. (2000). DOI: 10.1074/jbc.M004512200 https://www.ncbi.nlm.nih.gov/pubmed/11006272
MC025 Homo sapiens \ Mito, Energy/Precursor supply Leukotriene B4 Lipid.Eicosanoid Leukotriene B4 receptor 1 \ Inflammation/Immunity Wang et al. (2000). DOI: 10.1074/jbc.M004512200 https://www.ncbi.nlm.nih.gov/pubmed/11006272
MC026 Homo sapiens \ Mito, Energy/Precursor supply Leukotriene B4 Lipid.Eicosanoid Leukotriene B4 receptor 2 \ Inflammation/Immunity Jackson et al. (1992). PMID: 1320692 https://www.ncbi.nlm.nih.gov/pubmed/1320692
MC027 Homo sapiens \ Mito. Matrix Biotin Metabolite Tyrosine-protein kinase ABL1 \ Cell Growth, Differentiation Regulation The Scripps Research Institute Molecular Screening Center. (2012). PubChem AID: 602181 https://pubchem.ncbi.nlm.nih.gov/bioassay/602181
MC028 Rattus norvegicus \ Mito. Matrix, TCA GTP(Guanosine triphosphate) Metabolite D(2) dopamine receptor \ Dopaminergic Neuromodulation Van Tol et al. (1991). DOI: 10.1038/350610a0 https://www.ncbi.nlm.nih.gov/pubmed/1840645
MC029 Homo sapiens \ Mito. Matrix (OXPHOS) AMP(Adenosine monophosphate) Metabolite 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLC-IP3-DAG pathway Cell Fate Decision, Stress Adaptation The Scripps Research Institute Molecular Screening Center. (2014). PubChem AID: 743328 https://pubchem.ncbi.nlm.nih.gov/bioassay/743328
MC030 Homo sapiens \ Mito. Matrix (OXPHOS) AMP(Adenosine monophosphate) Metabolite 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] PLC-IP3-DAG pathway Cell Fate Decision, Stress Adaptation The Scripps Research Institute Molecular Screening Center. (2014). PubChem AID: 743329 https://pubchem.ncbi.nlm.nih.gov/bioassay/743329
MC031 Rattus norvegicus \ Mito. Matrix (OXPHOS) AMP(Adenosine monophosphate) Metabolite Adenosine receptor A2a cAMP-PKA-CREB(Activation) Inflammation/Immunity van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC032 Homo sapiens \ Mito. Matrix (OXPHOS) AMP(Adenosine monophosphate) Metabolite Glycogen synthase kinase-3 beta \ Glycogen Metabolism Regulation (impacts Metabolic Homeostasis) Broad Institute. (2010). PubChem AID: 434954 https://pubchem.ncbi.nlm.nih.gov/bioassay/434954
MC033 Homo sapiens \ Mito. Matrix (OXPHOS) AMP(Adenosine monophosphate) Metabolite L-lactate dehydrogenase A chain \ Glycolysis Regulation, Metabolic Homeostasis Ward et al. (2012). DOI: 10.1021/jm201734r https://www.ncbi.nlm.nih.gov/pubmed/22417091
MC034 Homo sapiens \ Mito. Matrix (OXPHOS) dATP(Deoxyadenosine triphosphate) Metabolite P2X purinoceptor 2 \ Apoptosis, Cell Death Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC035 Homo sapiens \ Mito. Matrix (OXPHOS) dATP(Deoxyadenosine triphosphate) Metabolite P2X purinoceptor 3 \ Apoptosis, Cell Death Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC036 Rattus norvegicus \ Mito. Inner Membrane Adenosine Metabolite Adenosine receptor A1 cAMP-PKA-CREB(Inhibition) Neuroprotection, Lifespan Bruns et al. (1986). PMID: 3010074 https://www.ncbi.nlm.nih.gov/pubmed/3010074
MC037 Rattus norvegicus \ Mito. Inner Membrane Adenosine Metabolite Adenosine receptor A2a cAMP-PKA-CREB(Activation) Inflammation/Immunity Bruns et al. (1986). PMID: 3010074 https://www.ncbi.nlm.nih.gov/pubmed/3010074
MC038 Homo sapiens \ Mito. Inner Membrane Adenosine Metabolite Glycogen synthase kinase-3 beta \ Glycogen Metabolism, Metabolic Homeostasis Broad Institute. (2010). PubChem AID: 434954 https://pubchem.ncbi.nlm.nih.gov/bioassay/434954
MC039 Homo sapiens \ Mito. Inner Membrane Adenosine Metabolite Heat shock 70 kDa protein 1A \ Proteostasis Maintenance Williamson et al. (2009). DOI: 10.1021/jm801627a https://www.ncbi.nlm.nih.gov/pubmed/19256508
MC040 Homo sapiens \ Mito. Matrix Cholic acid Lipid.Hormone G-protein coupled bile acid receptor 1 \ Metabolic Homeostasis Pellicciari et al. (2007). DOI: 10.1021/jm070633p https://www.ncbi.nlm.nih.gov/pubmed/17685603
MC041 Escherichia coli \ Mito, Energy supply Indoleacetic acid SmallMolecule Trp operon repressor \ Regulation of Amino Acid Homeostasis Marmorstein et al. (1987). PMID: 3549712 https://www.ncbi.nlm.nih.gov/pubmed/3549712
MC042 Escherichia coli \ Mito. Matrix, Amino acid metabolism L-Valine SmallMolecule Bifunctional aspartokinase/homoserine dehydrogenase 1 \ Regulation of Amino Acid Homeostasis Angeles et al. (1992). DOI: 10.1021/bi00118a023 https://www.ncbi.nlm.nih.gov/pubmed/1731937
MC043 Homo sapiens \ Mito. Matrix (OXPHOS) ADP(Adenosine Diphosphate) Metabolite Endoplasmic reticulum chaperone BiP Activation of the Unfolded Protein Response (UPR) ER Protein Folding, Proteostasis Macias et al. (2011). DOI: 10.1021/jm101625x https://www.ncbi.nlm.nih.gov/pubmed/21526763
MC044 Homo sapiens \ Mito. Matrix (OXPHOS) ADP(Adenosine Diphosphate) Metabolite Heat shock 70 kDa protein 1A \ Proteostasis Maintenance Macias et al. (2011). DOI: 10.1021/jm101625x https://www.ncbi.nlm.nih.gov/pubmed/21526763
MC045 Homo sapiens \ Mito. Matrix (OXPHOS) ADP(Adenosine Diphosphate) Metabolite P2X purinoceptor 2 NLRP3 inflammasome Pro-inflammatory Signaling Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC046 Homo sapiens \ Mito. Matrix (OXPHOS) ADP(Adenosine Diphosphate) Metabolite P2X purinoceptor 3 \ Inflammation Jarvis et al. (2004). DOI: 10.1124/jpet.103.064907 https://www.ncbi.nlm.nih.gov/pubmed/15024037
MC047 Rattus norvegicus \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule 5-hydroxytryptamine receptor 7 \ Neuromodulation (Cross-talk) Greenberg et al. (1976). DOI: 10.1016/0024-3205(76)90375-1 https://www.ncbi.nlm.nih.gov/pubmed/7724
MC048 Rattus norvegicus \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule D(2) dopamine receptor \ Neuromodulation (Cross-talk) Billard et al. (1984). DOI: 10.1016/0024-3205(84)90540-x https://www.ncbi.nlm.nih.gov/pubmed/6387355
MC049 Homo sapiens \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Gamma-aminobutyric acid receptor subunit alpha-1 \ Neuromodulation Ebert et al. (1997). PMID: 9396785 https://www.ncbi.nlm.nih.gov/pubmed/9396785
MC050 Homo sapiens \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Gamma-aminobutyric acid receptor subunit alpha-3 \ Neuromodulation Ebert et al. (1997). PMID: 9396785 https://www.ncbi.nlm.nih.gov/pubmed/9396785
MC051 Homo sapiens \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Gamma-aminobutyric acid receptor subunit alpha-5 \ Neuromodulation Ebert et al. (1997). PMID: 9396785 https://www.ncbi.nlm.nih.gov/pubmed/9396785
MC052 Homo sapiens \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Gamma-aminobutyric acid receptor subunit alpha-6 \ Neuromodulation Ebert et al. (1997). PMID: 9396785 https://www.ncbi.nlm.nih.gov/pubmed/9396785
MC053 Homo sapiens \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Gamma-aminobutyric acid receptor subunit rho-3 \ Neuromodulation Chang et al. (2000). DOI: 10.1124/mol.58.6.1375 https://www.ncbi.nlm.nih.gov/pubmed/11093776
MC054 Mus musculus \ Mito. Matrix gamma-Aminobutyric acid SmallMolecule Heat shock factor protein 1 \ Protein Quality Control, Stress Adaptation Broad Institute. (2010). PubChem AID: 2382 https://pubchem.ncbi.nlm.nih.gov/bioassay/2382
MC055 Homo sapiens \ Mito, Steroidogenesis Deoxycorticosterone Steroid Hormone 5-hydroxytryptamine receptor 2B \ Integrative Neuromodulation Nelson et al. (1999). DOI: 10.1007/pl00005315 https://www.ncbi.nlm.nih.gov/pubmed/9933142
MC056 Homo sapiens \ Mito, Steroidogenesis Deoxycorticosterone Steroid Hormone 5-hydroxytryptamine receptor 2C \ Integrative Neuromodulation Nelson et al. (1999). DOI: 10.1007/pl00005315 https://www.ncbi.nlm.nih.gov/pubmed/9933142
MC057 Escherichia coli \ Mito. Matrix, Amino acid metabolism L-alanine SmallMolecule Bifunctional aspartokinase/homoserine dehydrogenase 1 \ Regulation of Amino Acid Homeostasis Angeles et al. (1992). DOI: 10.1021/bi00118a023 https://www.ncbi.nlm.nih.gov/pubmed/1731937
MC058 Homo sapiens \ Mito. Matrix L-Aspartic acid SmallMolecule N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase \ Protein Quality Control Risley et al. (2001). DOI: 10.1080/14756360109162375 https://www.ncbi.nlm.nih.gov/pubmed/11697047
MC059 Rattus norvegicus \ Mito. Inner Membrane CDP Metabolite Adenosine receptor A1 cAMP-PKA-CREB(Inhibition) Purinergic Signaling van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC060 Rattus norvegicus \ Mito. Inner Membrane CDP Metabolite Adenosine receptor A2a cAMP-PKA-CREB(Activation) Cross-talk in Purinergic Signaling van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC061 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 Regulation of protein glycosylation Post-translational Modification (Epigenetic/Protein Mod) Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC062 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite 72 kDa type IV collagenase \ Extracellular Matrix Remodeling Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC063 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite Alpha-(1,3)-fucosyltransferase 7 Regulation of protein glycosylation Post-translational Modification (Epigenetic/Protein Mod) Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC064 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Regulation of protein sialylation Post-translational Modification (Epigenetic/Protein Mod) Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC065 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite Disintegrin and metalloproteinase domain-containing protein 17 \ Inflammation/Immunity Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC066 Homo sapiens \ Mito. Matrix, TCA GDP(Guanosine diphosphate) Metabolite Matrilysin \ Extracellular Matrix Remodeling Niu et al. (2004). DOI: 10.1016/j.abb.2004.02.039 https://www.ncbi.nlm.nih.gov/pubmed/15081893
MC067 Homo sapiens \ Mito, Steroidogenesis Cortisol Steroid Hormone Mineralocorticoid receptor \ Metabolic Homeostasis Edelman et al.(Allergan). (2019). US patent: US10188667 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10188667
MC068 Homo sapiens \ Mito, Steroidogenesis Cortisol Steroid Hormone Rho GTPase-activating protein 35 \ Cell Growth and Morphology Regulation Edelman et al.(Allergan). (2019). US patent: US10188667 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10188667
MC069 Mus musculus \ Mito, Steroidogenesis Cortisol Steroid Hormone Glucocorticoid receptor \ Metabolic Homeostasis El Masry et al. (1978). DOI: 10.1021/jm00219a005 https://www.ncbi.nlm.nih.gov/pubmed/926113
MC070 Rattus norvegicus \ Mito, One-carbon metabolism, NADPH supply Thymidine Metabolite Adenosine receptor A1 cAMP-PKA-CREB(Inhibition) Purine-Pyrimidine Metabolism Crosstalk van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC071 Rattus norvegicus \ Mito, One-carbon metabolism, NADPH supply Thymidine Metabolite Adenosine receptor A2a cAMP-PKA-CREB(Activation) Purine-Pyrimidine Metabolism Crosstalk van Galen et al. (1994). PMID: 8022403 https://www.ncbi.nlm.nih.gov/pubmed/8022403
MC072 Homo sapiens \ Mito. Inner Membrane Pyrophosphate Metabolite Carbonic anhydrase 1 \ Metabolic Homeostasis Del Prete et al. (2016). DOI: 10.1016/j.bmc.2016.05.029 https://www.ncbi.nlm.nih.gov/pubmed/27283786
MC073 Homo sapiens \ Mito. Inner Membrane Pyrophosphate Metabolite Carbonic anhydrase 2 \ Metabolic Homeostasis Del Prete et al. (2016). DOI: 10.1016/j.bmc.2016.05.029 https://www.ncbi.nlm.nih.gov/pubmed/27283786
MC074 Homo sapiens \ Mito. Matrix Thiamine Metabolite Carbonic anhydrase 1 \ Enzyme Activity Regulation Ozdemir et al. (2013). DOI: 10.3109/14756366.2011.637200 https://www.ncbi.nlm.nih.gov/pubmed/22145674
MC075 Homo sapiens \ Mito. Matrix Thiamine Metabolite Carbonic anhydrase 2 \ Enzyme Activity Regulation Ozdemir et al. (2013). DOI: 10.3109/14756366.2011.637200 https://www.ncbi.nlm.nih.gov/pubmed/22145674
MC076 Escherichia coli \ Mito. Matrix Thiamine Metabolite Thiamine-binding periplasmic protein \ Thiamine Transport Soriano et al. (2008). DOI: 10.1021/bi7018282 https://www.ncbi.nlm.nih.gov/pubmed/18177053
MC077 Homo sapiens \ Mito. Inner Membrane Hydrogen cyanide SmallMolecule Carbonic anhydrase 1 \ Metabolic Homeostasis Innocenti et al. (2009). DOI: 10.1016/j.bmcl.2008.12.082 https://www.ncbi.nlm.nih.gov/pubmed/19128966
MC078 Mus musculus \ Mito. Inner Membrane Hydrogen cyanide SmallMolecule Carbonic anhydrase 15 [19-324] \ Metabolic Homeostasis Innocenti et al. (2009). DOI: 10.1016/j.bmcl.2008.12.082 https://www.ncbi.nlm.nih.gov/pubmed/19128966
MC079 Homo sapiens \ Mito. Inner Membrane Hydrogen cyanide SmallMolecule Carbonic anhydrase 2 \ Metabolic Homeostasis Innocenti et al. (2009). DOI: 10.1016/j.bmcl.2008.12.082 https://www.ncbi.nlm.nih.gov/pubmed/19128966
MC080 Homo sapiens \ Mito. Inner Membrane Hydrogen cyanide SmallMolecule Carbonic anhydrase 4 \ Metabolic Homeostasis Innocenti et al. (2009). DOI: 10.1016/j.bmcl.2008.12.082 https://www.ncbi.nlm.nih.gov/pubmed/19128966
MC081 Homo sapiens \ Mito, Steroidogenesis Aldosterone Steroid Hormone Mineralocorticoid receptor \ Mineral, Fluid Homeostasis Edelman et al.(Allergan). (2019). US patent: US10188667 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10188667
MC082 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin A2 Lipid.Eicosanoid Dual specificity protein phosphatase 1 \ Cell Cycle, Stress Adaptation University of Pittsburgh. (2006). PubChem AID: 442 https://pubchem.ncbi.nlm.nih.gov/bioassay/442
MC083 Rattus norvegicus \ Mito, Energy/Precursor supply Prostaglandin A2 Lipid.Eicosanoid Dual specificity protein phosphatase 6 \ Cell Cycle, Stress Adaptation University of Pittsburgh. (2006). PubChem AID: 452 https://pubchem.ncbi.nlm.nih.gov/bioassay/452
MC084 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin A2 Lipid.Eicosanoid M-phase inducer phosphatase 2 \ Cell Cycle, Stress Adaptation University of Pittsburgh. (2006). PubChem AID: 443 https://pubchem.ncbi.nlm.nih.gov/bioassay/443
MC085 Homo sapiens \ Mito, Energy/Precursor supply Prostaglandin A2 Lipid.Eicosanoid Tyrosine-protein phosphatase non-receptor type 7 \ Cell Cycle, Stress Adaptation Burnham Center For Chemical Genomics. (2008). PubChem AID: 521 https://pubchem.ncbi.nlm.nih.gov/bioassay/521
MC086 Homo sapiens \ Mito. Matrix, beta-Oxidation gamma-Linolenic acid Lipid.FattyAcid 3-oxo-5-alpha-steroid 4-dehydrogenase 2 \ Lipid Metabolism, Inflammatory Precursor Fouche et al. (CSIR, Pretoria (Za)). (2015). US patent: US9061023 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9605427
MC087 Homo sapiens \ Mito, Energy/Precursor supply for Phe catabolism Phenylacetic acid SmallMolecule Aldo-keto reductase family 1 member B1 [C299A] \ Metabolic Homeostasis Brownlee et al. (2006). DOI: 10.1016/j.bioorg.2006.09.004 https://www.ncbi.nlm.nih.gov/pubmed/17083960
MC088 Homo sapiens \ Mito, Energy/Precursor supply for Phe catabolism Phenylacetic acid SmallMolecule Aldo-keto reductase family 1 member B1 [W220Y,C299A] \ Metabolic Homeostasis Brownlee et al. (2006). DOI: 10.1016/j.bioorg.2006.09.004 https://www.ncbi.nlm.nih.gov/pubmed/17083960
MC089 Saccharomyces cerevisiae \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Alpha-glucosidase MAL12 \ Metabolic Homeostasis Kashima et al. (2013). DOI: 10.3109/14756366.2012.719503 https://www.ncbi.nlm.nih.gov/pubmed/23009660
MC090 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 1 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC091 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 12 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC092 Mus musculus \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 13 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC093 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 14 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC094 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 2 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC095 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 3 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC096 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 4 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC097 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 5A, mitochondrial \ Mitochondrial Metabolism Regulation Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC098 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 5B, mitochondrial \ Mitochondrial Metabolism Regulation Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC099 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 7 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC100 Homo sapiens \ Mito, ETC, CoQ biosynthesis precursor 4-hydroxybenzoic acid SmallMolecule Carbonic anhydrase 9 \ Metabolic Homeostasis Innocenti et al. (2008). DOI: 10.1016/j.bmc.2008.06.013 https://www.ncbi.nlm.nih.gov/pubmed/18579385
MC101 Homo sapiens \ Mito, TCA Citric acid Metabolite Hepatocyte nuclear factor 4-alpha \ Metabolic Homeostasis The Scripps Research Institute Molecular Screening Center. (2012). PubChem AID: 651720 https://pubchem.ncbi.nlm.nih.gov/bioassay/651720
MC102 Homo sapiens \ Mito TCA Citric acid Metabolite Perilipin-1 \ Lipid Droplet Dynamics, Metabolic Homeostasis The Scripps Research Institute Molecular Screening Center. (2013). PubChem AID: 651672 https://pubchem.ncbi.nlm.nih.gov/bioassay/651672
MC103 Homo sapiens \ Mito TCA Citric acid Metabolite Perilipin-5 \ Lipid Droplet-Mitochondria Crosstalk, Metabolic Homeostasis The Scripps Research Institute Molecular Screening Center. (2012). PubChem AID: 651677 https://pubchem.ncbi.nlm.nih.gov/bioassay/651677
MC104 Homo sapiens \ Mito TCA Citric acid Metabolite Proto-oncogene tyrosine-protein kinase Src [145-252] \ Cell Migration/Invasion , Cytoskeletal Dynamics Lange et al. (2003). DOI: 10.1021/jm020970s https://www.ncbi.nlm.nih.gov/pubmed/14613321
MC105 Homo sapiens \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived Ribosyldihydronicotinamide dehydrogenase [quinone] \ Antioxidant Defense Maiti et al. (2009). DOI: 10.1021/jm801335z https://www.ncbi.nlm.nih.gov/pubmed/19265439
MC106 Homo sapiens \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived Melatonin receptor type 1A \ Circadian Rhythm Regulation Reppert et al. (1995). DOI: 10.1073/pnas.92.19.8734 https://www.ncbi.nlm.nih.gov/pubmed/7568007
MC107 Homo sapiens \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived Melatonin receptor type 1B \ Circadian Rhythm Regulation Reppert et al. (1995). DOI: 10.1073/pnas.92.19.8734 https://www.ncbi.nlm.nih.gov/pubmed/7568007
MC108 Homo sapiens \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived 5-hydroxytryptamine receptor 2B \ Integrative Neuromodulation Wainscott et al. (1996). PMID: 8632342 https://www.ncbi.nlm.nih.gov/pubmed/8632342
MC109 Homo sapiens \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived 5-hydroxytryptamine receptor 2C \ Integrative Neuromodulation Wainscott et al. (1996). PMID: 8632342 https://www.ncbi.nlm.nih.gov/pubmed/8632342
MC110 Rattus norvegicus \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived 5-hydroxytryptamine receptor 7 \ Neuromodulation Shen et al. (1993). PMID: 8394362 https://www.ncbi.nlm.nih.gov/pubmed/8394362
MC111 Rattus norvegicus \ Mito, Energy/Precursor supply Melatonin Hormone.Amino Acid-Derived 5-hydroxytryptamine receptor 2A \ Neuromodulation Millan et al. (2003). DOI: 10.1124/jpet.103.051797 https://www.ncbi.nlm.nih.gov/pubmed/12750432
MC112 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 1E \ Neuromodulation Zgombick et al. (1992). PMID: 1513320 https://www.ncbi.nlm.nih.gov/pubmed/1513320
MC113 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 1B \ Neuromodulation Weinshank et al. (1992). DOI: 10.1073/pnas.89.8.3630 https://www.ncbi.nlm.nih.gov/pubmed/1565658
MC114 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 1D \ Neuromodulation Weinshank et al. (1992). DOI: 10.1073/pnas.89.8.3630 https://www.ncbi.nlm.nih.gov/pubmed/1565658
MC115 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 7 \ Integrative Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC116 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 6 \ Integrative Neuromodulation Bard et al. (1993). PMID: 8226867 https://www.ncbi.nlm.nih.gov/pubmed/8226867
MC117 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 1F \ Neuromodulation Adham et al. (1993). DOI: 10.1073/pnas.90.2.408 https://www.ncbi.nlm.nih.gov/pubmed/8380639
MC118 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 2C \ Integrative Neuromodulation Nelson et al. (1993). PMID: 8510008 https://www.ncbi.nlm.nih.gov/pubmed/8510008
MC119 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 2B \ Integrative Neuromodulation Wainscott et al. (1996). PMID: 8632342 https://www.ncbi.nlm.nih.gov/pubmed/8632342
MC120 Homo sapiens \ Mito, Energy supply Tryptamine SmallMolecule Trace amine-associated receptor 1 \ Neuromodulation Borowsky et al. (2001). DOI: 10.1073/pnas.151105198 https://www.ncbi.nlm.nih.gov/pubmed/11459929
MC121 Mus musculus \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 4 \ Integrative Neuromodulation Bard et al. (1993). PMID: 8226867 https://www.ncbi.nlm.nih.gov/pubmed/8226867
MC122 Rattus norvegicus \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 2A \ Integrative Neuromodulation McKenna et al. (1989). PMID: 2795135 https://www.ncbi.nlm.nih.gov/pubmed/2795135
MC123 Rattus norvegicus \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 1A \ Integrative Neuromodulation Gozlan et al. (1983). DOI: 10.1038/305140a0 https://www.ncbi.nlm.nih.gov/pubmed/6225026
MC124 Rattus norvegicus \ Mito, Energy supply Tryptamine SmallMolecule 5-hydroxytryptamine receptor 7 \ Integrative Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC125 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule Ribosyldihydronicotinamide dehydrogenase [quinone] \ Antioxidant Defense Calamini et al. (2008). DOI: 10.1042/BJ20071373 https://www.ncbi.nlm.nih.gov/pubmed/18254726
MC126 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1B \ Neuromodulation Hamblin et al. (1992). DOI: 10.1016/0006-291x(92)90654-4 https://www.ncbi.nlm.nih.gov/pubmed/1315531
MC127 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1E \ Neuromodulation Zgombick et al. (1992). PMID: 1513320 https://www.ncbi.nlm.nih.gov/pubmed/1513320
MC128 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1D \ Neuromodulation Weinshank et al. (1992). DOI: 10.1073/pnas.89.8.3630 https://www.ncbi.nlm.nih.gov/pubmed/1565658
MC129 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule Melatonin receptor type 1B \ Circadian Rhythm Regulation Reppert et al. (1995). DOI: 10.1073/pnas.92.19.8734 https://www.ncbi.nlm.nih.gov/pubmed/7568007
MC130 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 2B \ Integrative Neuromodulation Bonhaus et al. (1995). DOI: 10.1111/j.1476-5381.1995.tb14977.x https://www.ncbi.nlm.nih.gov/pubmed/7582481
MC131 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1F \ Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC132 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 7 \ Integrative Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC133 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 6 \ Integrative Neuromodulation Bard et al. (1993). PMID: 8226867 https://www.ncbi.nlm.nih.gov/pubmed/8226867
MC134 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule Sodium-dependent dopamine transporter \ Neuromodulation (Serotonin-Dopamine Crosstalk) Pristupa et al. (1994). PMID: 8302271 https://www.ncbi.nlm.nih.gov/pubmed/8302271
MC135 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 2C \ Integrative Neuromodulation Nelson et al. (1993). PMID: 8510008 https://www.ncbi.nlm.nih.gov/pubmed/8510008
MC136 Homo sapiens \ Mito, Energy/Precursor supply Serotonin SmallMolecule D(2) dopamine receptor \ Neuromodulation (Serotonin-Dopamine Crosstalk) Seeman et al. (1997). DOI: 10.1002/(SICI)1098-2396(199702)25: 2 https://www.ncbi.nlm.nih.gov/pubmed/9021894
MC137 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 5A \ Neuromodulation Plassat et al. (1992). PMID: 1464308 https://www.ncbi.nlm.nih.gov/pubmed/1464308
MC138 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1F \ Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC139 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 3A \ Integrative Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC140 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 5B \ Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC141 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 6 \ Integrative Neuromodulation Unsworth et al. (1994). PMID: 8169832 https://www.ncbi.nlm.nih.gov/pubmed/8169832
MC142 Mus musculus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 4 \ Integrative Neuromodulation Ansanay et al. (1996). DOI: 10.1016/0014-2999(95)00786-5 https://www.ncbi.nlm.nih.gov/pubmed/8867105
MC143 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1B \ Neuromodulation Matsumoto et al. (1992). PMID: 1738111 https://www.ncbi.nlm.nih.gov/pubmed/1738111
MC144 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule D(2) dopamine receptor \ Neuromodulation (Serotonin-Dopamine Crosstalk) Andersen et al. (1985). DOI: 10.1016/0024-3205(85)90028-1 https://www.ncbi.nlm.nih.gov/pubmed/2415793
MC145 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule Sodium-dependent dopamine transporter \ Neuromodulation (Serotonin-Dopamine Crosstalk) Andersen et al. (1989). DOI: 10.1016/0014-2999(89)90363-4 https://www.ncbi.nlm.nih.gov/pubmed/2530094
MC146 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 2A \ Integrative Neuromodulation McKenna et al. (1989). PMID: 2795135 https://www.ncbi.nlm.nih.gov/pubmed/2795135
MC147 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 1A \ Integrative Neuromodulation Gozlan et al. (1983). DOI: 10.1038/305140a0 https://www.ncbi.nlm.nih.gov/pubmed/6225026
MC148 Rattus norvegicus \ Mito, Energy/Precursor supply Serotonin SmallMolecule 5-hydroxytryptamine receptor 7 \ Integrative Neuromodulation Boess et al. (1994). DOI: 10.1016/0028-3908(94)90059-0 https://www.ncbi.nlm.nih.gov/pubmed/7984267
MC149 Homo sapiens \ Mito, Steroidogenesis Estradiol Steroid Hormone G-protein coupled estrogen receptor 1 \ Reproductive, Neuroendocrine Physiology Revankar et al. (2007). DOI: 10.1021/cb700072n https://www.ncbi.nlm.nih.gov/pubmed/17655271
MC150 Homo sapiens/Mus musculus \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Alpha-2A adrenergic receptor \ Stress Response, Energy Mobilization Jasper et al. (1998). DOI: 10.1016/s0006-2952(97)00631-x https://www.ncbi.nlm.nih.gov/pubmed/9605427
MC151 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Beta-2 adrenergic receptor \ Stress Response, Energy Mobilization Hoffmann et al. (2004). DOI: 10.1007/s00210-003-0860-y https://www.ncbi.nlm.nih.gov/pubmed/14730417
MC152 Homo sapiens \ Mito, Steroidogenesis Testosterone Steroid Hormone Cholinesterase \ Metabolic Homeostasis Al-Aboudi et al. (2009). DOI: 10.1080/14756360802236393 https://www.ncbi.nlm.nih.gov/pubmed/18728994
MC153 Homo sapiens \ Mito, Steroidogenesis Testosterone Steroid Hormone Androgen receptor \ Reproductive Physiology Gryder et al. (2013). DOI: 10.1021/cb400542w https://www.ncbi.nlm.nih.gov/pubmed/24004176
MC154 Mus musculus \ Mito, Steroidogenesis Testosterone Steroid Hormone Androgen receptor \ Reproductive Physiology Labrie et al. (ENDORECHERCHE, INC.). (2017). US patent: US9682960 https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9682960
MC155 Homo sapiens \ Mito. Matrix, Amino acid metabolism L-Tyrosine SmallMolecule Tubulin--tyrosine ligase \ Cellular Behavior Banerjee et al. (2010). DOI: 10.1021/cb100060v https://www.ncbi.nlm.nih.gov/pubmed/20545322
MC156 Homo sapiens \ Mito, Steroidogenesis Androstenedione Steroid Hormone Cholinesterase \ Metabolic Homeostasis Al-Aboudi et al. (2009). DOI: 10.1080/14756360802236393 https://www.ncbi.nlm.nih.gov/pubmed/18728994
MC157 Homo sapiens \ Mito, Steroidogenesis Dihydrotestosterone Steroid Hormone Androgen receptor \ Reproductive Physiology Sun et al. (2006). DOI: 10.1021/jm061101w https://www.ncbi.nlm.nih.gov/pubmed/17181141
MC158 Rattus norvegicus \ Mito, Steroidogenesis Dihydrotestosterone Steroid Hormone Androgen receptor \ Reproductive Physiology Dalton et al. (1998). DOI: 10.1006/bbrc.1998.8209 https://www.ncbi.nlm.nih.gov/pubmed/9514878
MC159 Mus musculus \ Mito, NADPH supply 2-hydroxyestradiol SmallMolecule Heat shock factor protein 1 \ Protein Quality Control, Stress Adaptation Broad Institute. (2010). PubChem AID: 435004 https://pubchem.ncbi.nlm.nih.gov/bioassay/435004
MC160 Homo sapiens \ Mito, Energy supply Iodotyrosine SmallMolecule fMet-Leu-Phe receptor \ Innate Immune Cell Activation (Inflammation) NMMLSC. (2007). PubChem AID: 519 https://pubchem.ncbi.nlm.nih.gov/bioassay/519
MC161 Homo sapiens \ Mito, Energy supply Iodotyrosine SmallMolecule N-formyl peptide receptor 2 \ Innate Immune Cell Activation (Inflammation) NMMLSC. (2007). PubChem AID: 520 https://pubchem.ncbi.nlm.nih.gov/bioassay/520
MC162 Mus musculus \ Mito, Energy/Precursor supply Thromboxane A2 Lipid.Eicosanoid Thromboxane A2 receptor \ Systemic Homeostasis Armstrong et al. (1983). DOI: 10.1111/j.1476-5381.1983.tb10541.x https://www.ncbi.nlm.nih.gov/pubmed/6317122
MC163 Homo sapiens \ Mito, Energy (ATP) and Ca²⁺ signaling Leukotriene D4 Lipid.Eicosanoid Leukotriene B4 receptor 2 \ Inflammation/Immunity Heise et al. (2000). DOI: 10.1074/jbc.M003490200 https://www.ncbi.nlm.nih.gov/pubmed/10851239
MC164 Homo sapiens \ Mito, Energy (ATP) and Ca²⁺ signaling Leukotriene D4 Lipid.Eicosanoid Leukotriene B4 receptor 1 \ Inflammation/Immunity Wang et al. (2000). DOI: 10.1074/jbc.M004512200 https://www.ncbi.nlm.nih.gov/pubmed/11006272
MC165 Homo sapiens \ Mito, Energy/Precursor supply Leukotriene E4 Lipid.Eicosanoid Leukotriene B4 receptor 2 \ Inflammation/Immunity Heise et al. (2000). DOI: 10.1074/jbc.M003490200 https://www.ncbi.nlm.nih.gov/pubmed/10851239
MC166 Homo sapiens \ Mito, Energy/Precursor supply Leukotriene E4 Lipid.Eicosanoid Leukotriene B4 receptor 1 \ Inflammation/Immunity Wang et al. (2000). DOI: 10.1074/jbc.M004512200 https://www.ncbi.nlm.nih.gov/pubmed/11006272
MC167 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Alpha-1A adrenergic receptor \ Stress Response, Energy Mobilization Schwinn et al. (1995). PMID: 7815325 https://www.ncbi.nlm.nih.gov/pubmed/7815325
MC168 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Alpha-2B adrenergic receptor \ Stress Response, Energy Mobilization Jasper et al. (1998). DOI: 10.1016/s0006-2952(97)00631-x https://www.ncbi.nlm.nih.gov/pubmed/9606427
MC169 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Alpha-2C adrenergic receptor \ Stress Response, Energy Mobilization Jasper et al. (1998). DOI: 10.1016/s0006-2952(97)00631-x https://www.ncbi.nlm.nih.gov/pubmed/9606427
MC170 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Beta-1 adrenergic receptor \ Stress Response, Energy Mobilization Hoffmann et al. (2004). DOI: 10.1007/s00210-003-0860-y https://www.ncbi.nlm.nih.gov/pubmed/14730417
MC171 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Beta-3 adrenergic receptor \ Stress Response, Energy Mobilization Hoffmann et al. (2004). DOI: 10.1007/s00210-003-0860-y https://www.ncbi.nlm.nih.gov/pubmed/14730417
MC172 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Nuclear receptor subfamily 0 group B member 1 \ Stress Response, Energy Mobilization The Scripps Research Institute Molecular Screening Center. (2013). PubChem AID: 687017 https://pubchem.ncbi.nlm.nih.gov/bioassay/687017
MC173 Homo sapiens \ Mito, Energy supply Epinephrine Hormone.Amino Acid-Derived Steroidogenic factor 1 \ Stress Response, Energy Mobilization The Scripps Research Institute Molecular Screening Center. (2013). PubChem AID: 687018 https://pubchem.ncbi.nlm.nih.gov/bioassay/687018
MC174 Homo sapiens \ Mito, Steroidogenesis Testosterone Steroid Hormone Voltage-dependent L-type calcium channel subunit alpha-1C \ Metabolic Homeostasis Wisniowska et al. (2016). DOI: 10.1002/jat.2784 https://www.ncbi.nlm.nih.gov/pubmed/22761000
MC175 Homo sapiens \ Mito, Energy/Precursor supply 2-arachidonyl-glycerol Lipid Cannabinoid receptor 2 \ Energy Homeostasis, Neuromodulation Han et al. (2013). DOI: 10.1021/jm4005626 https://www.ncbi.nlm.nih.gov/pubmed/23865723
MC176 Rattus norvegicus \ Mito, Energy/Precursor supply 2-arachidonyl-glycerol Lipid Cannabinoid receptor 1 \ Energy Homeostasis, Neuromodulation Han et al. (2013). DOI: 10.1021/jm4005626 https://www.ncbi.nlm.nih.gov/pubmed/23865723
MC177 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 22(R)-hydroxycholesterol Sterol.Oxysterol Oxysterols receptor LXR-beta \ Sterol Homeostasis Singh et al. (2005). DOI: 10.1016/j.bmcl.2005.03.100 https://www.ncbi.nlm.nih.gov/pubmed/15911262
MC178 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 22(R)-hydroxycholesterol Sterol.Oxysterol Nuclear receptor ROR-gamma \ Immune van Niel et al. (2014). DOI: 10.1016/j.bmcl.2014.10.037 https://www.ncbi.nlm.nih.gov/pubmed/25453817
MC179 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Estrogen receptor beta \ Reproductive Physiology, Metabolism Zhi et al. (2003). DOI: 10.1016/s0960-894x(03)00255-5 https://www.ncbi.nlm.nih.gov/pubmed/12781197
MC180 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Sterol O-acyltransferase 1 \ Metabolic Homeostasis DeVries et al. (1987). DOI: 10.1021/jm00157a002 https://www.ncbi.nlm.nih.gov/pubmed/3100794
MC181 Homo sapiens \ Mito, Steroidogenesis Deoxycorticosterone Steroid Hormone 5-hydroxytryptamine receptor 2A \ Integrative Neuromodulation Nelson et al. (1999). DOI: 10.1007/pl00005315 https://www.ncbi.nlm.nih.gov/pubmed/9933142
MC182 Homo sapiens \ Mito, Steroidogenesis Estrone Steroid Hormone Estrogen receptor \ Reproductive Physiology, Metabolism Gungor et al. (2006). DOI: 10.1021/jm0509389 https://www.ncbi.nlm.nih.gov/pubmed/16610787
MC183 Homo sapiens \ Mito, Steroidogenesis Estrone Steroid Hormone Estrogen receptor beta \ Reproductive Physiology, Metabolism Gungor et al. (2006). DOI: 10.1021/jm0509389 https://www.ncbi.nlm.nih.gov/pubmed/16610787
MC184 Homo sapiens \ Mito, Steroidogenesis Estrone Steroid Hormone Ghrelin O-acyltransferase \ Metabolic Homeostasis McGovern-Gooch et al. (2017). DOI: 10.1021/acs.biochem.6b01008 https://www.ncbi.nlm.nih.gov/pubmed/28134508
MC185 Homo sapiens \ Mito, Steroidogenesis Dehydroepiandrosterone(Prasterone) Steroid Hormone NPC1-like intracellular cholesterol transporter 1 \ Neuroendocrine Regulation Popovic et al. (2013). DOI: 10.1074/jbc.M113.518506 https://www.ncbi.nlm.nih.gov/pubmed/24126916
MC186 Escherichia coli \ Mito, Steroidogenesis Dehydroepiandrosterone(Prasterone) Steroid Hormone Beta-glucuronidase \ Xenobiotic Metabolism Choudhary et al. (2012). DOI: 10.3109/14756366.2011.590804 https://www.ncbi.nlm.nih.gov/pubmed/21774747
MC187 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Progesterone receptor \ Reproductive Physiology, Metabolism Lee et al. (2007). DOI: 10.1016/j.chembiol.2007.06.006 https://www.ncbi.nlm.nih.gov/pubmed/17656319
MC188 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Mineralocorticoid receptor \ Mineral, Fluid Homeostasis Zhi et al. (2003). DOI: 10.1021/jm020477g https://www.ncbi.nlm.nih.gov/pubmed/12954062
MC189 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Androgen receptor \ Reproductive Physiology Zhi et al. (2003). DOI: 10.1021/jm020477g https://www.ncbi.nlm.nih.gov/pubmed/12954062
MC190 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Cholesterol Sterol.Cholesterol Oxysterols receptor LXR-alpha \ Sterol Homeostasis Spencer et al. (2001). DOI: 10.1021/jm0004749 https://www.ncbi.nlm.nih.gov/pubmed/11300870
MC191 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Cholesterol Sterol.Cholesterol Oxysterol-binding protein 2 \ Sterol Homeostasis Charman et al. (2014). DOI: 10.1074/jbc.M114.571216 https://www.ncbi.nlm.nih.gov/pubmed/24742681
MC192 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Cholesterol Sterol.Cholesterol Oxysterol-binding protein 2 [1-181,275-916] \ Sterol Homeostasis Charman et al. (2014). DOI: 10.1074/jbc.M114.571216 https://www.ncbi.nlm.nih.gov/pubmed/24742681
MC193 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Progesterone Steroid Hormone Glucocorticoid receptor \ Metabolic Homeostasis Zhi et al. (2003). DOI: 10.1021/jm020477g https://www.ncbi.nlm.nih.gov/pubmed/12954062
MC194 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 25-hydroxycholesterol Sterol.Oxysterol NPC1-like intracellular cholesterol transporter 1 \ Sterol Homeostasis, Immune Regulation Ohgane et al. (2014). DOI: 10.1016/j.bmcl.2014.05.064 https://www.ncbi.nlm.nih.gov/pubmed/24928400
MC195 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 25-hydroxycholesterol Sterol.Oxysterol Oxysterols receptor LXR-alpha \ Sterol Homeostasis, Immune Regulation Jayasuriya et al. (2005). DOI: 10.1021/np050182g https://www.ncbi.nlm.nih.gov/pubmed/16124770
MC196 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 25-hydroxycholesterol Sterol.Oxysterol Oxysterol-binding protein 2 \ Sterol Homeostasis Charman et al. (2014). DOI: 10.1074/jbc.M114.571216 https://www.ncbi.nlm.nih.gov/pubmed/24742681
MC197 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 25-hydroxycholesterol Sterol.Oxysterol Nuclear receptor ROR-gamma \ Immune Cell Differentiation van Niel et al. (2014). DOI: 10.1016/j.bmcl.2014.10.037 https://www.ncbi.nlm.nih.gov/pubmed/25453817
MC198 Homo sapiens \ Mito(neuronal), Oxysterol synthesis 24(S)-hydroxycholesterol Sterol.Oxysterol Oxysterols receptor LXR-alpha \ Sterol Homeostasis Spencer et al. (2001). DOI: 10.1021/jm0004749 https://www.ncbi.nlm.nih.gov/pubmed/11300870
MC199 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 27-hydroxycholesterol Sterol.Oxysterol Oxysterols receptor LXR-alpha \ Sterol Homeostasis, Systemic Homeostasis Spencer et al. (2001). DOI: 10.1021/jm0004749 https://www.ncbi.nlm.nih.gov/pubmed/11300870
MC200 Homo sapiens \ Mito. Matrix, Oxysterol synthesis 22(R)-hydroxycholesterol Sterol.Oxysterol Oxysterols receptor LXR-alpha \ Sterol Homeostasis Spencer et al. (2001). DOI: 10.1021/jm0004749 https://www.ncbi.nlm.nih.gov/pubmed/11300870
MC201 Homo sapiens \ Mito, Energy/Precursor supply 2-arachidonyl-glycerol Lipid Cannabinoid receptor 1 \ Energy Homeostasis, Neuromodulation Suhara et al. (2006). DOI: 10.1016/j.bmc.2006.10.049 https://www.ncbi.nlm.nih.gov/pubmed/17110113
MC202 Mus musculus \ Mito, Energy/Precursor supply 2-arachidonyl-glycerol Lipid Fatty acid-binding protein, liver \ Lipid Transport and Metabolism Huang et al. (2016). DOI: 10.1021/acs.biochem.6b00446 https://www.ncbi.nlm.nih.gov/pubmed/27552286
MC203 Caenorhabditis elegans Mitochondrial protein stress Mito TIM/TOM ATFS-1 Protein \ ATFS-1: Nuclear UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling, Mitochondrial proteases Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC204 Homo sapiens/Mus musculus Mitochondrial protein stress Mitochondria ATF-5 Protein \ ATF5, NRF2: Nuclear UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC205 Homo sapiens/Mus musculus Viral Infection, ISR Mito. Matrix/IMS DELE1 Protein \ DAP3, OMA1, DELE1, HRI, elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC206 Homo sapiens/Mus musculus ER stress Mitochondria Unfolded proteins, Ca2+ Metabolite.Protein \ PERK, elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC207 Homo sapiens/Mus musculus Viral stress Mitochondria dsRNA Nucleic acid \ PKR, elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC208 Homo sapiens/Mus musculus Amino acids starvation Mitochondria Amino acid Metabolite \ GCN2, elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC209 Homo sapiens/Mus musculus Low heme Mito. Matrix Heme Metabolite \ HRI, elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC210 Homo sapiens/Mus musculus Mitochondrial stress Mitochondria ATFS1, DELE1, HSP60 Protein \ elF2 alpha, ATF4: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC211 Homo sapiens/Mus musculus Low oxygen or Oxidative stress Mito TOM NMRR1 Protein \ NMRR1: NMRR1, RBPJ(Kappa) Response to O2 levels Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC212 Homo sapiens/Mus musculus Low oxygen or Oxidative stress Mito TOM D10 Protein \ D10: D10, CXX5 RNA processing stress response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC213 Homo sapiens/Mus musculus Low oxygen or Oxidative stress Mito TOM D10 Protein \ D10, TDP43: D10, TDP43 RNA processing stress response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC214 Homo sapiens Low oxygen or Oxidative stress Mito. Matrix MOTS-c Peptide.MDP \ MOTS-c: MOTS-c, ARE Antioxidant response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC215 Homo sapiens/Mus musculus Low oxygen or Oxidative stress Mito TOM CoQ7 Protein.Enzyme \ CoQ7: CoQ7 Antioxidant response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC216 Saccharomyces cerevisiae Low oxygen or Oxidative stress Mito TOM CoQ7 Protein.Enzyme \ CoQ7: CoQ7 Antioxidant response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC217 Caenorhabditis elegans \ Mitochondria CLK-1 Protein \ CLK-1: Nuclear Mito-Nuclear communication Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC218 Homo sapiens/Mus musculus \ Mito, ETC ROS SmallMolecule \ ROS: HIF-1 alpha Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC219 Homo sapiens/Mus musculus DNA damage Mito. IMS AIF Protein \ AIF, CYPA: AIF Chromatin condensation and DNA fragmentation, Cell Death Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC220 Homo sapiens/Mus musculus DNA damage Mito. IMS EndoG Protein \ EndoG: EndoG, g-H2AX DNA repair, DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC221 Homo sapiens/Mus musculus DNA damage Mito. OM FH Protein.Enzyme \ FH: Nuclear Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC222 Homo sapiens/Mus musculus DNA damage Mito enzyme HK2 Protein.Enzyme \ HK2, IPO5: HK2 Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC223 Homo sapiens/Mus musculus DNA damage Mitochondria HIGD1A Protein \ HIGD1A, NUP93: HIGD1A-RPA HR(Homologous Recombination), DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC224 Saccharomyces cerevisiae DNA damage Mitochondria RCF1 Protein \ RCF1: Nuclear Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC225 Homo sapiens/Mus musculus DNA damage Mito. OM BCL-2 Protein \ BCL-2: BCL-2-Ku70-Ku80 NHEJ(Non-Homologous End Joining), DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC226 Homo sapiens/Mus musculus DNA damage Mito. OM BCL-2 Protein \ BCL-2: BCL-2-APE1 BER(Base Excision Repair), DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC227 Homo sapiens/Mus musculus DNA damage Mito. OM BCL-2 Protein \ BCL-2: BCL-2-PARP1 Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC228 Homo sapiens/Mus musculus DNA damage Mito. OM BCL-2 Protein \ Bcl2-BRCA1 HR(Homologous Recombination), DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC229 Homo sapiens/Mus musculus DNA damage Mito. IMS Cyt c Protein \ Cyt-c: Nuclear Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC230 Homo sapiens/Mus musculus DNA damage Mito. IMS Cyt c Protein \ Cyt-c: Cyt-c, SET/NRP1 Nucleosome assembly, DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC231 Homo sapiens/Mus musculus DNA damage Mito. OM DRP1 Protein \ DPR1, hHR23A: DRP1 DNA repair, DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC232 Saccharomyces cerevisiae Epigenetic stress Mito TCA AcCoA, Citrate, Succinate Metabolite \ Rad23, Chromatin remodeling Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC233 Homo sapiens/Mus musculus DNA damage Mitochondria CRIF1 Protein \ CRF1-CDK2: CRF1-CDK2 DNA repair, DNA-damage response Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC234 Homo sapiens/Mus musculus DNA damage Mitochondria CRIF1 Protein \ CRIF1: CRF1-GADD45 Epigenetic modifications Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC235 Caenorhabditis elegans UPRmt Neuronal Serotonin SmallMolecule.Neurotransmitter 5-HT DCVs: intestine UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC236 Caenorhabditis elegans UPRmt Neuronal FLP-2 Peptide.Mitokine \ ATFS-1 UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC237 Caenorhabditis elegans UPRmt, ETC disruption, Mito dynamics imbalance Neuron mito stress FLP-2 Peptide.Mitokine SRZ-75 ATFS-1 UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Dodge et al. (2024). DOI: 10.1016/j.semcdb.2023.02.002 https://www.ncbi.nlm.nih.gov/pubmed/36792440
MC238 Caenorhabditis elegans PolyQ Stress Neuron mito stress Wnt/EGL-20 Protein.Mitokine MIG-1 Destruction complex, Beta-catenin: DVE-1, ATFS-1, LIN-65, JMJD UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Dodge et al. (2024). DOI: 10.1016/j.semcdb.2023.02.002 https://www.ncbi.nlm.nih.gov/pubmed/36792440
MC239 Caenorhabditis elegans UPRmt ADL neurons nlp-55 Peptide.Mitokine \ Suppresses the induction of peripheral UPRMT: peripheral UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC240 Caenorhabditis elegans UPRmt ADL neurons nlp-67 Peptide.Mitokine \ Peripheral UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC241 Caenorhabditis elegans UPRmt ADL neurons nlp-76 Peptide.Mitokine \ Peripheral, Intestine UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC242 Caenorhabditis elegans UPRmt ADL neurons daf-28 Peptide.Mitokine \ Peripheral UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC243 Caenorhabditis elegans UPRmt ADL neurons ins-14 Peptide.Mitokine \ Activate UPRMT in the intestine, peripheral, Intestine UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC244 Caenorhabditis elegans UPRmt, ETC disruption, Mito dynamics imbalance Neuron mito stress ins-27 Peptide.Mitokine DAF-2 \ UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Dodge et al. (2024). DOI: 10.1016/j.semcdb.2023.02.002 https://www.ncbi.nlm.nih.gov/pubmed/36792440
MC245 Caenorhabditis elegans UPRmt, ETC disruption, Mito dynamics imbalance Neuron mito stress ins-35 Peptide.Mitokine DAF-2 \ UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Dodge et al. (2024). DOI: 10.1016/j.semcdb.2023.02.003 https://www.ncbi.nlm.nih.gov/pubmed/36792440
MC246 Homo sapiens OXPHOS dysfunction Hepatic GDF15 Protein.Mitokine \ Extracellular ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC247 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatic GDF15 Protein.Mitokine GFRAL,hindbrain Downstream signaling pathways: Nuclear ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC248 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatic GDF15 Protein.Mitokine \ ATF4, CHOP: Extracellular ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC249 Homo sapiens OXPHOS dysfunction Hepatic FGF21 Protein.Mitokine FGFR1c/beta-Klotho Extracellular ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC250 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatic FGF21 Protein.Mitokine FGFR1c/beta-Klotho \ ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC251 Homo sapiens/Mus musculus OXPHOS dysfunction, ATF4/CHOP Hepatic FGF21 Protein.Mitokine Beta-klotho, a co-receptor for FGF21 ATF4 ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC252 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatic FGF21 Protein.Mitokine Beta-klotho, a co-receptor for FGF21 iWAT ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC253 Homo sapiens/Mus musculus Mitochondrial dysfunction, Amino acid deprivation Liver, Adipose tissue, Pancreas, Muscle FGF21 Protein.Hormone FGFR1c/beta-Klotho AMPK-SIRT1-PGC-1 alpha, MAPK/ERK, PI3K/Akt Enhance mitochondrial biogenesis, fatty acid oxidation Yan et al. (2021). DOI: 10.3389/fcvm.2021.655575 https://www.ncbi.nlm.nih.gov/pubmed/33869312
MC254 Homo sapiens/Mus musculus Mitochondrial dysfunction, Amino acid deprivation Liver, Adipose tissue, Pancreas, Muscle FGF21 Protein.Hormone FGFR1c/beta-Klotho MAPK/ERK, PI3K/Akt Increase energy expenditure Yan et al. (2021). DOI: 10.3389/fcvm.2021.655575 https://www.ncbi.nlm.nih.gov/pubmed/33869312
MC255 Homo sapiens/Mus musculus Mitochondrial dysfunction, Amino acid deprivation Liver, Adipose tissue, Pancreas, Muscle FGF21 Protein.Hormone FGFR1c/beta-Klotho PI3K/Akt Improve insulin sensitivity, Anti-inflammation Yan et al. (2021). DOI: 10.3389/fcvm.2021.655575 https://www.ncbi.nlm.nih.gov/pubmed/33869312
MC256 Homo sapiens/Mus musculus Mitochondrial dysfunction, ER stress, Amino acid deprivation Multiple tissues ATF-4 Protein (Intracellular) Transcriptional activation of GDF21 and FGF21 genes Master regulator of integrated stress response, Induces mitokine production Kang et al. (2021). DOI: 10.1016/j.isci.2021.102181 https://www.ncbi.nlm.nih.gov/pubmed/33718833
MC257 Homo sapiens/Mus musculus Mitochondrial dysfunction, Amino acid deprivation, ER stress Liver, Other tissues FGF21 Protein.Hormone FGFR1c/beta-Klotho Inhibition of ISR (eIF2 alpha dephosphorylation), Promotion of ATF4 degradation Negative feedback on mitochondrial integrated stress response, Attenuate cellular stress Kang et al. (2021). DOI: 10.1016/j.isci.2021.102181 https://www.ncbi.nlm.nih.gov/pubmed/33718833
MC258 Homo sapiens/Mus musculus Mitochondrial dysfunction, ER stress, Amino acid deprivation Multiple tissues GDF15 Protein.Hormone GFRAL (in the brainstem) Activation of brainstem neuronal circuits Anorexia, Weight loss, Systemic metabolic adaptation Kang et al. (2021). DOI: 10.1016/j.isci.2021.102181 https://www.ncbi.nlm.nih.gov/pubmed/33718833
MC259 Homo sapiens/Mus musculus Mitochondrial myopathy, Oxidative stress in muscle Skeletal Muscle FGF21 Protein.Hormone FGFR1c/beta-Klotho (on adipose tissue) Downstream pathways in adipose tissue Endocrine signal of muscle stress, Induces adipose tissue remodeling , systemic metabolic adaptation Fisher et al. (2016). DOI: 10.1146/annurev-physiol-021115-105339 https://www.ncbi.nlm.nih.gov/pubmed/26654352
MC260 Mus musculus Cold exposure, Adrenergic signaling Brown & White Adipose Tissue FGF21 Protein.Hormone FGFR1c/beta-Klotho (locally) Thermogenic gene program (UCP1 induction) Adaptive thermogenesis, Browning of white fat Fisher et al. (2016). DOI: 10.1146/annurev-physiol-021115-105339 https://www.ncbi.nlm.nih.gov/pubmed/26654352
MC261 Homo sapiens/Mus musculus Nutrient excess, Obesity, Lipotoxicity Liver, Adipose tissue FGF21 Protein.Hormone FGFR1c/beta-Klotho Adiponectin secretion Improved systemic insulin sensitivity, Hepatic steatosis reduction Yan et al. (2021). DOI: 10.3389/fcvm.2021.655575 https://www.ncbi.nlm.nih.gov/pubmed/33869312
MC262 Homo sapiens/Mus musculus OXPHOS dysfunction Adrenal medulla ADM2 Protein.Mitokine \ PI3K-AKT signalling pathway: myocardial ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC263 Homo sapiens/Mus musculus OXPHOS dysfunction Adrenal medulla ADM2 Protein.Mitokine \ ADM2 stimulate the phosphorylation of ERK signalling: thyroid cancer ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC264 Homo sapiens/Mus musculus Mitochondrial Dysfunction (e.g., OXPHOS inhibition), ER Stress Cell (e. g. , hepatocyte, cancer cell) ATF-4 Protein \ ISRmt / UPR Stimulates ADM2 expression Activate stress-responsive gene expression Kovaleva et al. (2016). DOI: 10.1016/j.gene.2016.06.037 https://www.ncbi.nlm.nih.gov/pubmed/21909975
MC265 Rattus norvegicus ER Stress, Myocardial Ischemia/Reperfusion Cardiomyocyte ADM2 Protein.Hormone.Mitokine CRLR / RAMP1 PI3K/Akt, inhabit ATF4 Directly inhibits ATF4 overexpression, anti-apoptosis Teng et al. (2011). DOI: 10.1007/s00109-011-0808-5 https://www.ncbi.nlm.nih.gov/pubmed/27328455
MC266 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatocytes ANGPTL6 Protein.Mitokine \ Extracellular ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC267 Homo sapiens/Mus musculus OXPHOS dysfunction Hepatocytes ANGPTL6 Protein.Mitokine \ ERK-MAPK signaling pathway ISRmt(Integrated Stress Response) Zhang et al. (2023). DOI: 10.1093/lifemeta/load001 https://www.ncbi.nlm.nih.gov/pubmed/37538245
MC268 Mus musculus OXPHOS dysfunction Adipocytes ANGPTL6 Protein.Mitokine \ ERK-MAPK signaling pathway, Ppar alpha, FGF21: 3T3-L1 adipocytes ISRmt(Integrated Stress Response) Kang et al. (2017). DOI: 10.1530/JOE-16-0549 https://www.ncbi.nlm.nih.gov/pubmed/28184000
MC269 Mus musculus Genetic deficiency of Crif1 (impairs OXPHOS subunit synthesis and assembly) Adipocyte ANGPTL6 Protein.Hormone.Mitokine \ ERK/MAPK pathway, Ppar alpha expression and activity Paracrine induction of Fgf21, Enhancement of beta-oxidation in adipocytes Kang et al. (2017). DOI: 10.1530/JOE-16-0549 https://www.ncbi.nlm.nih.gov/pubmed/28184000
MC270 Homo sapiens Aging Mito. Matrix MOTS-c Peptide.MDP \ MOTS-c, NRF2: Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC271 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP \ Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC272 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP \ IGFBP-3, Bax, and tBid Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC273 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP \ IGFBP-3 Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC274 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP CNTFR/gp130/WSX-1 receptor \ Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC275 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP CNTFR/gp130/WSX-1 receptor JAK-STAT pathway Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC276 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP CNTFR/gp130/WSX-2 receptor Stat3 Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC277 Homo sapiens Aging Mito. Matrix Humanin Peptide.MDP FRPL1/2 (the formyl peptide receptor-like 1/2) receptor \ Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC278 Homo sapiens Aging Mito. Matrix MOTS-c Peptide.MDP \ AMPK: Extracellular Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC279 Homo sapiens Aging Mito. Matrix SHLP1 Peptide.MDP \ Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC280 Homo sapiens Aging Mito. Matrix SHLP2 Peptide.MDP \ ERK and STAT-3: Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC281 Homo sapiens Aging Mito. Matrix SHLP3 Peptide.MDP \ ERK and STAT-3: Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC282 Homo sapiens Aging Mito. Matrix SHLP4 Peptide.MDP \ Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC283 Homo sapiens Aging Mito. Matrix SHLP5 Peptide.MDP \ Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC284 Homo sapiens Aging Mito. Matrix SHLP6 Peptide.MDP \ Nuclear Longevity Lee et al. (2013). DOI: 10.1016/j.tem.2013.01.005 https://www.ncbi.nlm.nih.gov/pubmed/23402768
MC285 Homo sapiens/Mus musculus \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Nuclear Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC286 Homo sapiens \ Mito TCA alpha-Ketoglutarate(KG) Metabolite \ Nuclear Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC287 Homo sapiens \ Mito TCA Succinyl-CoA Metabolite \ Nuclear Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC288 Homo sapiens \ Mito. Matrix (OXPHOS) ATP Metabolite \ Nuclear Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC289 Homo sapiens \ Mito TCA Fumarate Metabolite \ Nuclear Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC290 Homo sapiens \ Mito TCA cycle metabolite aconitate Itaconate Metabolite \ KEAP1, NRF2: ER Cysteine alkylation Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC291 Homo sapiens \ Mito TCA Lysine, Tryptophan Metabolite \ Glutaryl-CoA, CPS1, ..., ER Epigenetic modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC292 Homo sapiens \ Mito Methionine metabolism SAM Metabolite \ Histone methylation: Nuclear Epigenetic modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC293 Homo sapiens \ Mito Methionine metabolism SAM Metabolite \ Cytosine 5methylation: Nuclear Epigenetic modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC294 Homo sapiens \ Mito Methionine metabolism SAM Metabolite \ Adenosine 6methylation: Nuclear Epigenetic modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC295 Homo sapiens \ Mito Methionine metabolism SAM Metabolite \ Non-histone protein methylation: Nuclear Epigenetic modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC296 Saccharomyces cerevisiae \ Mito. Matrix TPP, thiamine pyrophosphate Metabolite \ Ribosome Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC297 Saccharomyces cerevisiae \ Mito. Matrix, One-carbon metabolism, Purine synthesis Purines Metabolite \ Ribosome Post-translational modifications Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC298 Homo sapiens/Mus musculus \ Mito, ER PAHSA(FAHFA, fatty acid ester of hydroxyl fatty acid) Lipid GPR40 Ca2+, GLP1 insulin Metabolic Homeostasis Rinschen et al. (2019). DOI: 10.1038/s41580-019-0108-4 https://www.ncbi.nlm.nih.gov/pubmed/30814649
MC299 Homo sapiens mtDSBs Mito (BAX/BAK) mtDSBs (doublestrand breaks of the mtDNA) Nucleic acid \ BAX/BAK, mtRNA, RIG1, STAT1, ISGs: Nuclear Mito-Nuclear communication Rigon et al. (2021). DOI: 10.1016/j.cmet.2021.04.013 https://www.ncbi.nlm.nih.gov/pubmed/33951470
MC300 Homo sapiens mtDSBs (doublestrand breaks of the mtDNA) Mito (BAX/BAK) dsmtRNA(matrix contents) Nucleic acid \ STAT1 nuclear translocation: Nuclear, ISGs gene Mito-Nuclear communication Rigon et al. (2021). DOI: 10.1016/j.cmet.2021.04.013 https://www.ncbi.nlm.nih.gov/pubmed/33951470
MC301 Homo sapiens/Mus musculus \ Mitochondria Content(protein, etc) Protein \ Nanotunnel: Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC302 Homo sapiens/Mus musculus \ Mitochondria Membrane potential Physicochemical State Signals \ Membrane: Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC303 Homo sapiens/Mus musculus \ Mitochondria Content(protein, etc) Protein \ Fusion: Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC304 Homo sapiens/Mus musculus \ Mitochondria Content(protein, etc) Protein \ IMJ: Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC305 Homo sapiens \ Mitochondria Fatty acid oxidation Lipid \ Lipid droplets Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC306 Homo sapiens \ Mitochondria Lipids Lipid \ Peroxisomes Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC307 Homo sapiens \ Mitochondria MDVs Vesicle \ Lysosome Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC308 Homo sapiens \ Mitochondria MDVs Vesicle \ Peroxisomes Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC309 Homo sapiens \ Mito resident proteins TFAM Protein \ Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC310 Homo sapiens \ Mitochondria Apoptosis signal Protein \ Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC311 Homo sapiens/Mus musculus \ Mitochondria NRF1 Protein \ Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC312 Homo sapiens/Mus musculus \ Mitochondria NRF2 Protein \ Mitochondria Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC313 Homo sapiens/Mus musculus \ Mitochondria Ca2+ SmallMolecule \ ER Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC314 Homo sapiens/Mus musculus \ Mitochondria Ca2+ SmallMolecule \ Nuclear Organelle communication Boardman et al. (2023). DOI: 10.1210/endrev/bnad004 https://www.ncbi.nlm.nih.gov/pubmed/36725366
MC315 Homo sapiens \ Mito TCA alpha-Ketoglutarate(KG) Metabolite \ JMJDs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC316 Homo sapiens \ Mito TCA 2-HG Metabolite \ JMJDs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC317 Homo sapiens \ Mito TCA Fumarate Metabolite \ JMJDs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC318 Homo sapiens \ Mito TCA Fumarate Metabolite \ Inhibit JMJDs: Genome-wide histone methylation Mito-Nuclear communication Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC319 Homo sapiens \ Mito TCA Succinate Metabolite \ JMJDs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC320 Homo sapiens \ Mito TCA Succinate Metabolite \ Inhibit JMJDs: Genome-wide histone methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC321 Homo sapiens \ Mito Methionine metabolism SAM Metabolite \ HMTs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC322 Homo sapiens \ Mito. Matrix FAD Metabolite \ LSDs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC323 Homo sapiens \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Citrate, Acetyl-CoA, HATs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC324 Saccharomyces cerevisiae \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Hyperactivation of Acs2p/ACSS2: Histone(H2A/B, H3) acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC325 Caenorhabditis elegans \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ UPRmt activation: Histone(H3Ac) acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC326 Homo sapiens \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Reduction in neuronal plasticity: Histone(H3K9ac, H3K27ac, H4K12ac) acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC327 Saccharomyces cerevisiae \ Mito. Matrix (as electron carrier in ETC) NAD+ Metabolite \ Sir2 cofactor for the protein deacetylases sirtuins (SIRTs): histone acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC328 Caenorhabditis elegans \ Mito. Matrix (as electron carrier in ETC) NAD+ Metabolite \ Sir2 cofactor for the protein deacetylases sirtuins (SIRTs): histone acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC329 Homo sapiens \ Mito. Matrix (as electron carrier in ETC) NAD+ Metabolite \ Sir2 cofactor for the protein deacetylases sirtuins (SIRTs): histone acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC330 Saccharomyces cerevisiae \ Mito Methionine metabolism SAM Metabolite \ Unknown: Histone methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC331 Caenorhabditis elegans \ Mito Methionine metabolism SAM Metabolite \ Mimicking dietary restriction: Histone methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC332 Saccharomyces cerevisiae \ Mito Methionine metabolism Methionine Metabolite \ Retrograde response activation, increased stress tolerance, autophagy-dependent: Unknown Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC333 Caenorhabditis elegans \ Mito Methionine metabolism Methionine Metabolite \ Decreased in methionine levels: Unknown Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC334 Homo sapiens \ Mito Methionine metabolism Methionine Metabolite \ Decreased levels of glucose, T4, IGF-I, and insulin; increased levels of hepatocyte MIF; improved stress resistance: Unknown Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC335 Saccharomyces cerevisiae \ Mito. Matrix Spermidine Metabolite \ Inhibition of histone acetyltransferases activity, suppression of oxidative stress, activation of autophagy: histone(H3Ac) acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC336 Caenorhabditis elegans \ Mito. Matrix Spermidine Metabolite \ Inhibition of histone acetyltransferases activity, suppression of oxidative stress, activation of autophagy: histone(H4Ac) acetylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC337 Caenorhabditis elegans \ Mito TCA alpha-Ketoglutarate(KG) Metabolite \ JMJDs/TETs DNA demethylases cofactor: DNA methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC338 Homo sapiens \ Mito TCA alpha-Ketoglutarate(KG) Metabolite \ JMJDs/TETs DNA demethylases cofactor: DNA methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC339 Caenorhabditis elegans \ Mito TCA Fumarate Metabolite \ Inhibit TETs: DNA methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC340 Homo sapiens \ Mito TCA Fumarate Metabolite \ Inhibit TETs: DNA methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC341 Homo sapiens \ Mito TCA Succinate Metabolite \ Inhibit TETs: DNA methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC342 Homo sapiens \ Mito TCA 2-HG Metabolite \ TETs: Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC343 Saccharomyces cerevisiae \ Mito, ETC mtROS SmallMolecule \ Inactivation of a histone H3K36 demethylase Rph1p: H3K36me3 demethylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC344 Caenorhabditis elegans \ Mito, ETC mtROS SmallMolecule \ Inactivation of the SET1/MLL histone methyltransferases: H3K4me3 methylation Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC345 Caenorhabditis elegans \ Mito, ETC mtROS SmallMolecule \ Nuclear Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC346 Caenorhabditis elegans UPRmt(mitochondrial stress) acetyl-CoA decreased Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Nuclear accumulation(NuRD complex, the homeobox(TF) DVE-1): Histone acetylation, reorganize chromatin structure Epigenetic modifications Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC347 Mus musculus \ Mito TCA alpha-Ketoglutarate(KG) Metabolite \ \ Decreased levels of inflammatory cytokines Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC348 Mus musculus \ Mito TCA Succinate Metabolite \ \ Genome-wide histone and DNA methylation Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC349 Mus musculus \ Mito TCA Fumarate Metabolite \ \ Genome-wide histone and DNA methylation Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC350 Mus musculus \ Mito. Matrix (as electron carrier in ETC) NAD+ Metabolite \ \ Electron carrier in ETC Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC351 Mus musculus \ Mito Methionine metabolism Methionine Metabolite \ \ Decreased levels of glucose, T4, IGF-I, and insulin, increased levels of hepatocyte MIF, improved stress resistance Zhu et al. (2022). DOI: 10.1016/j.tibs.2022.03.008 https://www.ncbi.nlm.nih.gov/pubmed/35397926
MC352 Homo sapiens SDH defect Mito TCA Succinate Metabolite Sucnr1 \ Systemic signals Chakrabarty et al. (2022). DOI: 10.1042/bio_2022_119 https://www.ncbi.nlm.nih.gov/pubmed/36248614
MC353 Homo sapiens/Mus musculus Macrophage SDH defect Mito TCA Succinate Metabolite Sucnr1 P13K-HIF alpha: Arg1, Fizz1, Mgl1, Mgl2: TAM polarization IL-6, IL-6R, Immune Wu et al. (2020). DOI: 10.1016/j.molcel.2019.10.023 https://www.ncbi.nlm.nih.gov/pubmed/31735641
MC354 Homo sapiens/Mus musculus Cancer cell SDH defect Mito TCA Succinate Metabolite Sucnr1 P13K-HIF alpha: E-Carherin, N-Carherin, Vimentin Tumor metastasis Wu et al. (2020). DOI: 10.1016/j.molcel.2019.10.023 https://www.ncbi.nlm.nih.gov/pubmed/31735641
MC355 Homo sapiens/Mus musculus ROS upregulation Mito TCA, MCT(SLC16)/OAT(SLC22) Succinate Metabolite Sucnr1 ATP/cAMP/PKA Nuclear effect Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC356 Homo sapiens/Mus musculus ROS upregulation Mito TCA, MCT(SLC16)/OAT(SLC22) Succinate Metabolite Sucnr1 RAF, ERK1/2 Nuclear effect Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC357 Homo sapiens/Mus musculus ROS upregulation Mito TCA, MCT(SLC16)/OAT(SLC22) Succinate Metabolite Sucnr1 PLC, Ca2+/PKC Nuclear effect Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC358 Homo sapiens/Mus musculus Inflammation, Glycolysis Macrophage Succinate Metabolite.Hormone Sucnr1 P-CREB/KLF4, IL-10 Anti-inflammatory program Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC359 Mus musculus \ Adipocyte Succinate Metabolite.Hormone Sucnr1 Gi protein, AC inhibition, cAMP Metabolic Homeostasis, Antilipolysis Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC360 Mus musculus \ Kidney macula densa Succinate Metabolite Sucnr1 Renin release, RAS activation Blood pressure regulation Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC361 Mus musculus \ Intestinal tuft cell Succinate Metabolite Sucnr1 Type 2 immune response (e.g., IL-13) Pathogen defense, mucus secretion Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC362 Homo sapiens/Mus musculus Exercise Skeletal muscle Succinate Metabolite.Hormone Sucnr1 Activation of non-myofibrillar resident cells Muscle remodeling and adaptation Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC363 Mus musculus \ Brown adipocyte Succinate Metabolite N/A (Intracellular) Mitochondrial ROS production, Thermogenesis Body temperature maintenance Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC364 Homo sapiens/Mus musculus \ Gut microbiota / Intestine Succinate Metabolite N/A (Intracellular) Intestinal gluconeogenesis Improvement of glucose tolerance Fernandez-Veledo et al. (2021). DOI: 10.1016/j.tem.2021.06.003 https://www.ncbi.nlm.nih.gov/pubmed/34301438
MC365 Saccharomyces cerevisiae \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ \ Metabolic signal Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC366 Saccharomyces cerevisiae Apoptotic Mito. IMS Cyt c Protein \ \ Cell death, Apoptosis Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC367 Saccharomyces cerevisiae \ Mito TCA Fumarate Metabolite \ \ Metabolic signal Gonzalez-Arzola et al. (2023). DOI: 10.3390/ijms241713656 https://www.ncbi.nlm.nih.gov/pubmed/37686461
MC368 Homo sapiens Mito stress Mitochondria ATF-4, GDF15 Protein.Mitokine GFRAL \ ISRmt(Integrated Stress Response) Chakrabarty et al. (2022). DOI: 10.1042/bio_2022_119 https://www.ncbi.nlm.nih.gov/pubmed/36248614
MC369 Caenorhabditis elegans \ E. coil Colanic acid Metabolite \ Mitochondrial dynamics Interspecies signals Han et al. (2017). DOI: 10.1016/j.cell.2017.05.036 https://www.ncbi.nlm.nih.gov/pubmed/28622510
MC370 Homo sapiens Cellular Stress Mito resident protein(Matrix) HSP60 Protein Extracellular \ Metabolic, inflammatory, or other systemic signaling roles Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC371 Mus musculus MOXI Mitochondria Mitoregulin (MOXI) Peptide \ MOXI, MOXI-MTP, Beta-oxidation, MOXI(p), MOXI-Nat14-CJun: Nuclear Mito-Nuclear communication Cai et al. (2023). DOI: 10.1016/j.kint.2023.02.009 https://www.ncbi.nlm.nih.gov/pubmed/37085255
MC372 Mus musculus MOXI Mitochondria (MTP) MOXI (p) Peptide \ MOXI(p)-Nat14-CJun: Nuclear, collagen I MOXI, MOXI-MTP, Beta-oxidation, MOXI(p), MOXI-Nat14-CJun Cai et al. (2023). DOI: 10.1016/j.kint.2023.02.009 https://www.ncbi.nlm.nih.gov/pubmed/37085255
MC373 Mus musculus MOXI Mito. Matrix ATP, NAD+, ROS SmallMolecule \ Mitochondria-to-nucleus signaling: Nuclear, Fibrotic genes Mito-Nuclear communication Cai et al. (2023). DOI: 10.1016/j.kint.2023.02.009 https://www.ncbi.nlm.nih.gov/pubmed/37085255
MC374 Homo sapiens/Mus musculus Apoptotic stimulus, DNA damage Mito. IMS Cyt c Protein \ BCL-2/BH3-only proteins, BAX/BAK, Cytc, APAF1, Caspase9, Caspase3/7, Apoptosis Cell death, Apoptosis Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC375 Homo sapiens/Mus musculus Apoptotic stimulus, DNA damage Mito MOMP SMAC/OMI/others Protein \ BCL-2/BH3-only proteins, BAX/BAK, SMAC/OMI/others, XIAP, Caspase9, Caspase3/7, Apoptosis Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC376 Homo sapiens/Mus musculus apoptotic Mito MOMP IAPs Protein \ NIK, NF-(Kappa)B, Inflammation Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC377 Homo sapiens/Mus musculus apoptotic Mito MOMP dsRNA Nucleic acid \ MDA5, MAVs, IRF3, inflammation Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC378 Homo sapiens/Mus musculus apoptotic Mito MOMP PNPT1 Protein \ mRNA degradation Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC379 Homo sapiens/Mus musculus apoptotic Mito MOMP mtDNA Nucleic acid \ cGAS-STING, IRF3, Inflammation Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC380 Homo sapiens/Mus musculus Necroptosis Mito MOMP ROS SmallMolecule \ RIPK1, RIPK3, PDH, MLKL Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC381 Homo sapiens/Mus musculus Necroptosis Mito MOMP PDH Protein.Enzyme \ RIPK1, RIPK4, PDH, MLKL Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC382 Homo sapiens/Mus musculus Necroptosis Mito, ETC H2O2 SmallMolecule \ MLKL Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC383 Homo sapiens/Mus musculus Necroptosis Mito mPTP Ca2+ SmallMolecule \ MLKL Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC384 Homo sapiens/Mus musculus Pyroptosis Mito. IMS Cyt c Protein \ Caspases, Inflammasome Cell death, Pyroptosis Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC385 Homo sapiens/Mus musculus Ferroptosis Mitochondria ROS SmallMolecule \ Fenton reaction Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC386 Homo sapiens/Mus musculus Ferroptosis Mito. Matrix, Fe-S cluster biogenesis Fe2+ SmallMolecule \ Fenton reaction Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC387 Homo sapiens/Mus musculus Ferroptosis Mitochondria Glutaminolysis, alpha-ketoglutarate Metabolite \ Cysteine, GSH, GPX4 Cell death Bock et al. (2020). DOI: 10.1038/s41580-019-0173-8 https://www.ncbi.nlm.nih.gov/pubmed/31636403
MC388 Homo sapiens Apoptotic stimuli Mito. IMS AIF Protein \ Nuclear Cell death, Apoptosis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC389 Homo sapiens Apoptotic stimuli Mito. IMS Cyt c Protein \ Nuclear Cell death, Apoptotic signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC390 Homo sapiens \ Mito, ETC ROS SmallMolecule \ Nuclear Redox regulation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC391 Homo sapiens \ Mito, ETC ROS SmallMolecule \ ER Redox regulation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC392 Homo sapiens \ Mitochondria Cytoplasmic DNA&RNA Nucleic acid \ \ Systemic signals Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC393 Homo sapiens \ Mito DNA mtDNA Nucleic acid RNA/DNA sensors mtDNA-TLR9-MyD88, IRAK-1, IKB alpha-NFkB-ub: Nuclear Inflammation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC394 Homo sapiens \ Mitochondria cf-mtDNA Nucleic acid \ Extracellular Inflammation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC395 Homo sapiens \ Mitochondria mtRNA Nucleic acid RNA/DNA sensors Nuclear Inflammation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC396 Homo sapiens heat stress Mitochondria Heat Physicochemical State Signals \ \ Temperature, Mitochondrial Stress Signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC397 Homo sapiens \ Mito. Inner Membrane (matrix side), Steroidogenesis Pregnenolone Steroid Hormone CB1R Extracellular Endocrine, Systemic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC398 Homo sapiens \ Mito, Steroidogenesis Cortisol Steroid Hormone Mineralocorticoid receptor Extracellular Endocrine, Systemic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC399 Homo sapiens \ Mito, Steroidogenesis Cholest Steroid Hormone \ Nuclear Endocrine, Systemic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC400 Homo sapiens/Mus musculus Mito stress Mitochondria ATF-4 Protein \ Nuclear ISRmt(Integrated Stress Response) Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC401 Homo sapiens/Mus musculus ISR Mitochondria GPS2 Protein \ Nuclear UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC402 Homo sapiens/Mus musculus Viral Infection, ISR Mito. Matrix/IMS DELE1 Protein \ Nuclear UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC403 Homo sapiens/Mus musculus Mitochondrial inner membrane depolarization Mitochondria GPS2 (Desumoylated form) Protein Nuclear Transcription Complexes GPS2-mediated Transcription Induction of mitochondrial biogenesis Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC404 Homo sapiens/Mus musculus Bidirectional mt-transcription, PNPase deficiency Mitochondria mt-dsRNA Nucleic Acid RIG-I, MDA5, PKR RLR-MAVS Signaling, ISR Activates type I interferon response and antiviral immunity Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC405 Homo sapiens/Mus musculus Loss of membrane potential, Iron deficiency Mito. Matrix/IMS DELE1 (C-terminal fragment) Protein HRI (kinase in cytosol) Integrated Stress Response (ISR) Promotes cell survival, restores mitochondrial function, attenuates inflammation Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC406 Caenorhabditis elegans Mitochondrial proteotoxic stress Mitochondrial dysfunction ROS SmallMolecule HSF1 (HSP70-DNAJA1 complex) ROS oxidizes DNAJA1, HSF1 release, Nuclear translocation, Transcription of mitochondrial chaperones Enhances mitochondrial proteostasis and stress resistance Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC407 Caenorhabditis elegans Mitochondrial metabolic perturbation Mito, Reduced TCA cycle activity Acetyl-CoA depletion Metabolite NuRD complex Chromatin compaction via histone deacetylation, Selective activation of UPRmt genes Promotes mitochondrial stress response and longevity Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC408 Homo sapiens/Mus musculus Mitochondrial membrane damage Mitochondria mtDNA (via MDVs) Nucleic acid cGAS-STING MDV formation, mtDNA release, cGAS activation, STING-IRF3/7 signaling, Type I interferon production Activates innate immune response to mitochondrial damage Kim et al. (2024). DOI: 10.1083/jcb.202310005 https://www.ncbi.nlm.nih.gov/pubmed/38335010
MC409 Homo sapiens/Mus musculus \ Mitochondria MDVs Vesicle \ Cytosol Vesicular transport Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC410 Homo sapiens/Mus musculus \ Mitochondria MDVs Vesicle \ Extracellular Vesicular transport Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC411 Saccharomyces cerevisiae \ Mitochondria MDVs Vesicle \ Extracellular Vesicular transport Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC412 Saccharomyces cerevisiae Mito dysfunction Mito. Matrix (OXPHOS) ATP Metabolite RTG2 RTG1, RTG3: Nuclear Mito-Nuclear communication Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC413 Saccharomyces cerevisiae \ Mito, ETC ROS SmallMolecule \ Nuclear Mito-Nuclear communication Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC414 Saccharomyces cerevisiae \ Mitochondria Ca2+ SmallMolecule \ Nuclear Mito-Nuclear communication Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC415 Saccharomyces cerevisiae \ Mitochondria mtDNA Nucleic acid \ Nuclear Systemic signals Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC416 Homo sapiens/Mus musculus Dying cell Mito DNA mtDNA Nucleic acid cGAS-STING cGAS-STING: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC417 Homo sapiens/Mus musculus Dying cell Mito DNA mtDNA Nucleic acid TLR9 mtDNA-TLR9-MyD88, IRAK-1, IKB alpha-NFkB-ub: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC418 Homo sapiens/Mus musculus Dying cell Mito DNA mtDNA Nucleic acid TLR9 IRF7 (interferon regulatory factor-7): Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC419 Homo sapiens/Mus musculus Dying cell Mito DNA mtDNA Nucleic acid TLR9 TRAF7 (tumor-necrosis factor alpha receptor activated factor-6 ): Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC420 Homo sapiens/Mus musculus Dying cell Mito DNA mtDNA Nucleic acid NLRP3-inflammasome Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC421 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite NLRP3-inflammasome P2X, P2Y, NLRP3-inflammasome: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC422 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite NLRP3-inflammasome ATP, PCr, ATP, NLRP3-inflammasome: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC423 Homo sapiens/Mus musculus Dying cell Mito resident proteins TFAM Protein \ TFAM+IFN-Gamma: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC424 Homo sapiens/Mus musculus Dying cell Mito. Inner Membrane Cardiolipin Membrane.Lipid \ TLR2, IKB alpha-NFkB-ub: Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC425 Homo sapiens/Mus musculus Dying cell Mito. Inner Membrane Cardiolipin Membrane.Lipid \ Extracellular, (lung fluid Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC426 Homo sapiens/Mus musculus Dying cell Mito. Inner Membrane Cardiolipin Membrane.Lipid \ Extracellular, (skeletal muscle Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC427 Homo sapiens/Mus musculus Dying cell Mito. Inner Membrane Cardiolipin Membrane.Lipid \ TLR2PI3K-PKN1-AKT-p38MAPK-NFkB: antigen presenting cells Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC428 Homo sapiens/Mus musculus Dying cell Bacterial cells and mitochondria NFPs (N-formyl peptides ) Peptide FPRs(transmembrane G protein-coupled receptors) NFP, FPR, MAPK: Monocytes(Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC429 Homo sapiens/Mus musculus Dying cell Bacterial cells and mitochondria NFPs (N-formyl peptides ) Peptide FPRs(transmembrane G protein-coupled receptors) NFP, FPR, MAPK: Neutrophils(Nuclear Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC430 Homo sapiens/Mus musculus Dying cell Mito RNA mt-dsRNA Nucleic acid MDA5 RLRs, MAVs, NLRP3: Nuclear Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC431 Homo sapiens/Mus musculus Dying cell Mito RNA mt-dsRNA Nucleic acid RIG-1 RLRs, MAVs, NLRP3: Nuclear Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC432 Homo sapiens/Mus musculus Dying cell Mito. OM MAVs Protein \ NLRP3: Nuclear Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC433 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) eATP (extracellular ATP ) Metabolite \ The purinergic receptor subtype P2X receptor Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC434 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) eATP (extracellular ATP ) Metabolite \ The purinergic receptor subtype P3Y receptor Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC435 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ADP Metabolite \ eATP, ADP, P2: P2 receptors Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC436 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) AMP Metabolite \ eATP, AMP, P2: P2 receptors Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC437 Homo sapiens/Mus musculus Dying cell Mito. Inner Membrane adenosine Metabolite \ eATP, adenosine, P2: P2 receptors Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC438 Homo sapiens/Mus musculus Dying cell Mitochondria Each of these molecules SmallMolecule \ \ Inflammation Hill et al. (2018). DOI: 10.3389/fgene.2018.00225 https://www.ncbi.nlm.nih.gov/pubmed/30042784
MC439 Homo sapiens/Mus musculus \ Mito. Matrix (OXPHOS) ATP/ADP Metabolite \ \ Metabolic signal Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC440 Homo sapiens/Mus musculus \ Mito. Matrix (OXPHOS) AMP/ATP Metabolite \ AMPK, Mitofission+Mitophagy Metabolism Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC441 Homo sapiens/Mus musculus \ Mitochondria DAMPs, Metabolite Metabolite \ \ Systemic signals Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC442 Homo sapiens/Mus musculus \ Mito. Matrix (as electron carrier in ETC) NADH/NAD+ Metabolite SIRT1 Nuclear Epigenetic modifications Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC443 Homo sapiens/Mus musculus \ Mito TCA cycle metabolite aconitate Itaconate Metabolite \ Nuclear Inflammation Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC444 Homo sapiens/Mus musculus Necrosis Mito, ETC H2O2+Ca2+ SmallMolecule mPTP Necrosis Cell death Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC445 Homo sapiens/Mus musculus \ Mito, ETC H2O2 SmallMolecule \ Protein thiol modifications Cell physiology Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC446 Homo sapiens/Mus musculus Apoptotic Mito. IMS Cyt c Protein Apoptosome Caspases(apoptosome): Nuclear Cell death, Apoptosis Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC447 Homo sapiens/Mus musculus ISR Mito. Matrix (as electron carrier in ETC) NADH/NAD+ Metabolite \ GCN2-elF2 alpha, ISR Protein synthesis Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC448 Homo sapiens/Mus musculus \ Mito TCA Citrate Metabolite \ Acetyl-CoA, Acetylation Epigenetic modifications Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC449 Homo sapiens/Mus musculus \ Mito. Matrix (TCA, PDH, beta-oxidation) Acetyl-CoA Metabolite \ Acetylation Epigenetic modifications Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC450 Homo sapiens/Mus musculus \ Mitochondria Lipids Lipid \ \ Epigenetic modifications Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC451 Homo sapiens/Mus musculus \ Mito TCA Succinate Metabolite \ \ Epigenetic modifications Poor et al. (2023). DOI: 10.1016/j.molcel.2023.01.008 https://www.ncbi.nlm.nih.gov/pubmed/36931250
MC452 Homo sapiens/Mus musculus DNA damage Mito. Matrix (OXPHOS) ATP Metabolite P2X7R NLRP3 inflammasome Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC453 Homo sapiens/Mus musculus DNA damage Mitochondria Formyl peptides Peptide FPR(neutrophils) Chemotaxis and the respiratory burst Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC454 Homo sapiens/Mus musculus DNA damage Mitochondria ssRNA Nucleic acid \ MAVs(mito), NF-kB: IRF3, IRF7 Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC455 Homo sapiens/Mus musculus DNA damage Mitochondria dsRNA Nucleic acid \ MAVs(mito), NF-kB: IRF3, IRF7 Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC456 Homo sapiens/Mus musculus DNA damage Mito DNA mtDNA Nucleic acid \ \ Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC457 Homo sapiens/Mus musculus DNA damage Mito DNA mtDNA Nucleic acid \ NF-kB: IRF3, IRF7 Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC458 Homo sapiens/Mus musculus DNA damage Mito DNA mtDNA Nucleic acid TLR9,MyD88,TRIF TLR9, MyD88: NF-kB Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC459 Homo sapiens/Mus musculus DNA damage Mitochondria cf-mtDNA, mtDNA fragments Nucleic acid \ cGAS-STING, Inflammasome activation Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC460 Homo sapiens/Mus musculus DNA damage Mito, ETC ROS SmallMolecule \ NF-kB: IRF3, IRF7 Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC461 Homo sapiens/Mus musculus DNA damage Mito. Inner Membrane Cardiolipin Membrane.Lipid \ Upregulate pro-IL-1b: IL-1Beta Inflammation Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC462 Homo sapiens/Mus musculus Macrophage Mito, ETC ROS SmallMolecule \ HIF-alpha: inflammatory gene expression Immune Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC463 Homo sapiens/Mus musculus Macrophage Mito TCA cycle metabolite aconitate Itaconate Metabolite \ Antimicrobial effects Immune Banoth et al. (2018). DOI: 10.1016/j.trsl.2018.07.014 https://www.ncbi.nlm.nih.gov/pubmed/30165038
MC464 Homo sapiens/Mus musculus Apoptosis (MOMP) Mito. IMS (Bcl-2/BAK), BAX/BAK Cyt c Protein \ BAX/BAK(Bcl-2/BH3 only protein), Cyt c, Caspases, Apoptosis Cell death, Apoptosis Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC465 Homo sapiens/Mus musculus MPt Mito PTPC-PPIF Dysregulated ion SmallMolecule \ Closed PTPC, PPIF, Open PTPC, Regulated necrosis Cell death Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC466 Homo sapiens/Mus musculus MPt Mito PTPC-PPIF Water influx Physicochemical State Signals \ Closed PTPC, PPIF, Open PTPC, Regulated necrosis Cell death Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC467 Homo sapiens/Mus musculus Live cell Mito (BAX/BAK) ERAL-1, MAVS Protein \ RIG-I or MDA5: IL-6, IFNBeta1, TNF Immune activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC468 Homo sapiens/Mus musculus Live cell Mito BAX-BAK1 mtRNA Nucleic acid \ RIG-I, TBK1, IKK, IRF7, IRF3: IL-6, IFNBeta1, TNF Immune activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC469 Homo sapiens/Mus musculus Live cell Mito BAX-BAK2 mtRNA Nucleic acid \ MDA5, TBK1, IKK, IRF7, IRF3: IL-6, IFNBeta1, TNF Immune activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC470 Homo sapiens/Mus musculus Live cell Mito, PTPC mtDNA Nucleic acid \ cGAS-STING1(ER), TBK1, IKK, IRF7, IRF3: IL-6, IFNBeta1, TNF Immune activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC471 Homo sapiens/Mus musculus Live cell Mito BAX-BAK1 mtDNA Nucleic acid \ Inflammasome: IL-18, IL-1Beta Inflammation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC472 Homo sapiens/Mus musculus Live cell Mito, ETC ROS SmallMolecule \ NLRP3 inflammasome: IL-18, IL-1Beta Inflammation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC473 Homo sapiens/Mus musculus Live cell Mito, ETC PCr, ATP Metabolite \ Inflammasome: IL-18, IL-1Beta Inflammation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC474 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite P2RY2 PANX1: P2RY2, antigen-presenting cells (APCs) Chemotaxis and activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC475 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite P2RY2 Lysosome: P2RY2, antigen-presenting cells (APCs) Chemotaxis and activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC476 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite P2RX7 PANX1: P2RX7, antigen-presenting cells (APCs) Chemotaxis and activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC477 Homo sapiens/Mus musculus Dying cell Mito. Matrix (OXPHOS) ATP Metabolite P2RX7 Lysosome: P2RX7, antigen-presenting cells (APCs) Chemotaxis and activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC478 Homo sapiens/Mus musculus Dying cell Mito, BAX-BAK1 SMAC Protein \ IAP, NIK, Canonical NF-(Kappa)B: IL-6, IL-8 Inflammation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC479 Homo sapiens/Mus musculus Dead cell Mitochondria NFPs (N-formyl peptides ) Peptide FPR1,Neutrophi \ Neutrophil activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC480 Homo sapiens/Mus musculus Dead cell Mito, PTPC TFAM_x005f_x0002_bound mtDNA Protein TLR9,Neutrophi TLR9, Neutrophi Neutrophil activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC481 Homo sapiens/Mus musculus Dead cell Mito, PTPC Naked mtDNA Nucleic acid TLR9,Neutrophi TLR9, Neutrophi Neutrophil activation Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC482 Homo sapiens/Mus musculus Dead cell Mito. Inner Membrane Cardiolipin Membrane.Lipid \ CD1d(DC)-Cardiolipin-TCR(Gamma(deta)T cell) Gamma(delta)T cell activation, Immune Marchi et al. (2023). DOI: 10.1038/s41577-022-00760-x https://www.ncbi.nlm.nih.gov/pubmed/35879417
MC483 Saccharomyces cerevisiae \ Mito. Matrix NADPH Metabolite \ Nuclear Metabolism, aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC484 Saccharomyces cerevisiae \ Mito. Matrix, PDH, TCA Pyruvic acid Metabolite \ Nuclear Metabolism, aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC485 Saccharomyces cerevisiae \ Mito TCA Citrate Metabolite \ Peroxisomes Antioxidant response Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC486 Saccharomyces cerevisiae \ Mito. Inner Membrane Acetylcarnitine Metabolite \ Peroxisomes Antioxidant response Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC487 Saccharomyces cerevisiae \ Mito, Acetyl-CoA synthesis AcOH Metabolite \ Lysosome Pro-aging, Longevity Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC488 Saccharomyces cerevisiae \ Mito, Precursor supply (Acetyl-CoA) Triacylglycerols(TAG), lipid Lipid \ ER Membrane, Aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC489 Saccharomyces cerevisiae D and PD phase Mito. Matrix NADPH Metabolite \ TRR/GLR Protection of proteins from oxidative damage, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC490 Saccharomyces cerevisiae D and PD phase Mito. Matrix Glycerol, NAD+/NADH Metabolite \ \ Stress resistance, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC491 Saccharomyces cerevisiae D and PD phase Mito, Stress response coordination Trehalose Metabolite \ \ Maintenance of cellular proteostasis, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC492 Saccharomyces cerevisiae D and PD phase Mito, ETC Hormetic H2O2 SmallMolecule \ Gis1, Msn2/4: Stress response genes Stress resistance, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC493 Saccharomyces cerevisiae D and PD phase Mito, ETC H2O2 SmallMolecule \ Tell, Rad53, Rph1: Subtelomeric chromatin Telomeric DNA damage, Pro-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC494 Saccharomyces cerevisiae D and PD phase Mito. Matrix, Amino acid metabolism Amino acids Metabolite \ TORC1, Tap42, Protein synthesis Protein synthesis in the cytosol, Pro-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC495 Saccharomyces cerevisiae D and PD phase Mito. Matrix, Amino acid metabolism Amino acids Metabolite \ TORC1, Sch9, Protein synthesis Protein synthesis in mitochondria, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC496 Saccharomyces cerevisiae D and PD phase Mito. Matrix, Amino acid metabolism Amino acids Metabolite \ TORC1, Sch9: Stress response genes Stress resistance, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC497 Saccharomyces cerevisiae D and PD phase Mito. Matrix, Amino acid metabolism Amino acids Metabolite \ TORC1, ATG Autophagy, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC498 Saccharomyces cerevisiae D and PD phase Mito Methionine metabolism Methionine Metabolite \ TORC1, ATG Autophagy, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC499 Saccharomyces cerevisiae D and PD phase Mito. Matrix Spermidine Metabolite \ Sas3/Iki3: ATG Autophagy, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC500 Saccharomyces cerevisiae D and PD phase Mito tRNAs Cyc1 Protein \ Rtg1/2/3: Stress response genes Stress resistance, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC501 Saccharomyces cerevisiae D and PD phase Mito, Acetyl-CoA synthesis AcOH Metabolite \ AcCoA: ATG genes Autophagy, Anti-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC502 Saccharomyces cerevisiae ST phase Mito, Acetyl-CoA synthesis AcOH Metabolite \ \ Apoptosis, Pro-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC503 Saccharomyces cerevisiae ST phase Coupled respiration ATP Metabolite \ FFA\DAG Liponecrosis, Pro-aging Dakik et al. (2016). DOI: 10.3389/fgene.2016.00177 https://www.ncbi.nlm.nih.gov/pubmed/27729926
MC504 Caenorhabditis elegans Hypoxia, mito dysfunction Mito ETC isp-1 mutant ROS SmallMolecule \ HIF-1, Ftn-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC505 Caenorhabditis elegans Hypoxia, mito dysfunction Mito ETC clk-1 mutant ROS SmallMolecule \ HIF-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC506 Caenorhabditis elegans Hypoxia, mito dysfunction Mito, ETC ROS SmallMolecule \ HIF-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC507 Caenorhabditis elegans Mito ETC dysfunction Mito, ETC ROS SmallMolecule \ SKN-1(Nrf) Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC508 Caenorhabditis elegans Mito ETC dysfunction Mito ETC isp-1 mutant Succinate, ROS, GDF15 Metabolite.Protein \ CEH-23 Cell death, Apoptotic signaling Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC509 Caenorhabditis elegans Mito ETC dysfunction Mito ETC isp-1 mutant ROS SmallMolecule \ CEP-1(p53), Ftn-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC510 Caenorhabditis elegans Mito ETC dysfunction Mito ETC mev-1 mutant ROS SmallMolecule \ CEP-1(p53), Ftn-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC511 Caenorhabditis elegans Mito ETC dysfunction Mito ETC gas-1 mutant ROS SmallMolecule \ CEP-1(p53), Ftn-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC512 Caenorhabditis elegans Mito ETC dysfunction Mito ETC nuo-6 mutate ROS SmallMolecule \ CEP-1(p53), Ftn-1 Aging, Senescence Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC513 Caenorhabditis elegans Mito protein/dysfunction Mito TIM/TOM ATFS-1 Protein \ UBL-5, DEV-1, ATFS-1, UPRmt UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling, Mitochondrial proteases Chang et al. (2015). DOI: 10.1016/j.freeradbiomed.2014.10.576 https://www.ncbi.nlm.nih.gov/pubmed/25450327
MC514 Caenorhabditis elegans Mito mtDNA mutant Mito, mtDNA COX1 Protein.Enzyme \ Downregulated the nuclear dct-15 DNA regulation, aging Zhu et al. (2022). DOI: 10.1016/j.gene.2022.146776 https://www.ncbi.nlm.nih.gov/pubmed/36063972
MC515 Caenorhabditis elegans Mitochondrial protein stress Mito. Matrix ClpP, HAF-1 peptide Peptide \ UBL-5, DEV-1, ATFS-1, HSP60 UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling, Mitochondrial proteases Haynes et al. (2007). DOI: 10.1016/j.cmet.2014.01.011 https://www.ncbi.nlm.nih.gov/pubmed/17925224
MC516 Caenorhabditis elegans Apoptotic Mito, EGL-1, CED-3 Wah-1(AIF) Protein \ EGL-1, CED-3, Wah-1, CPS-6, DNA degradation Cell death, Apoptosis Wang et al. (2002). DOI: 10.1126/science.1076194 https://www.ncbi.nlm.nih.gov/pubmed/12446902
MC517 Saccharomyces cerevisiae Apoptotic Mito, Fis1, Dnm1 EndoG, AIF, ROS Protein \ Fis1, Dnm1, EndoG, AIF, ROS Cell death, Apoptosis Hardwick et al. (2004). DOI: 10.1016/j.devcel.2004.10.013 https://www.ncbi.nlm.nih.gov/pubmed/15525523
MC518 Homo sapiens/Mus musculus Apoptotic Mito, Bcl-2, Drp1 EndoG, AIF, Cyt c, ROS Protein \ Bcl-2, Drp1, EndoG, AIF, Cyt c, ROS Cell death, Apoptosis Hardwick et al. (2004). DOI: 10.1016/j.devcel.2004.10.013 https://www.ncbi.nlm.nih.gov/pubmed/15525523
MC519 Caenorhabditis elegans apoptotic Mito, CED-9, Drp1 CED-4 Protein \ CED-9/EGL-1, (Drp1), CED-4, CED-3, cell death Cell death Jagasia et al. (2005). DOI: 10.1038/nature03316 https://www.ncbi.nlm.nih.gov/pubmed/15716954
MC520 Saccharomyces cerevisiae Acetic acid, bostrycin, H2O2 Mito, apoptosis-inducing factor AIF1p Protein \ Pro-apoptotic released factor translocating to the nucleus Programmed cell death Guaragnella et al. (2012). DOI: 10.3389/fonc.2012.00070 https://www.ncbi.nlm.nih.gov/pubmed/22783546
MC521 Saccharomyces cerevisiae Acetic acid, amiodarone/alpha-factor, Bax heterologous, expression, H2O2, hyperosmotic stress, salt stress Mito. IMS Cyt c Protein \ Pro-apoptotic released factor, ETC electron donor, ROS scavenger Programmed cell death Guaragnella et al. (2012). DOI: 10.3389/fonc.2012.00070 https://www.ncbi.nlm.nih.gov/pubmed/22783546
MC522 Saccharomyces cerevisiae Acetic acid, amiodarone, ethanol, H2O2 Mitochondrial nuclease NUC1p (Endo G) Protein \ Pro-apoptotic released factor translocating to the nucleus Programmed cell death Guaragnella et al. (2012). DOI: 10.3389/fonc.2012.00070 https://www.ncbi.nlm.nih.gov/pubmed/22783546
MC523 Saccharomyces cerevisiae Apoptotic stimuli, Oxidative stress Mito, Ca2+, ROS, PTP opening Cytochrome c Protein \ ATP, Yca1p(caspase), cell death Programmed cell death Carraro et al. (2016). DOI: 10.1016/j.ceca.2016.03.005 https://www.ncbi.nlm.nih.gov/pubmed/26995056
MC524 Saccharomyces cerevisiae Death stimulus Mito. OM Dnm1 Protein \ Fis1, Dnm1, mitochon drial fragmentation, degradation Cell death, Dynamic Fannjiang et al. (2004). DOI: 10.1101/gad.1247904 https://www.ncbi.nlm.nih.gov/pubmed/15520274
MC525 Saccharomyces cerevisiae Hydroperoxide levels increase Mito, ETC H2O2 SmallMolecule \ H2O2, Gpx3/Orp1, Yap1: Nucleus, bZip Hydroperoxide homeostasis Delaunay et al. (2002). DOI: 10.1016/S0092-8674(02)01048-6 https://www.ncbi.nlm.nih.gov/pubmed/12437921
MC526 Saccharomyces cerevisiae Lacking amino acids or limited for nitrogen Mito. Matrix(arg synthesis enzyme) Arg5/6 Protein.Enzyme \ Arg5/6: Nucleus, transcription Regulation of Gene Expression Hall et al. (2004). DOI: 10.1126/science.1096773 https://www.ncbi.nlm.nih.gov/pubmed/15486299
MC527 Caenorhabditis elegans Moderate mitochondrial dysfunction Mito, ROS, SOD-3, PRDX-3, VDAC-1 H2O2 SmallMolecule \ SEK-1, NSY-1, PMK-3, p38 MAPK, KLF-1: Nucleus, KLF-1, CYPs Longevity-promoting genes Hermeling et al. (2022). DOI: 10.1016/j.redox.2022.102533 https://www.ncbi.nlm.nih.gov/pubmed/36442394
MC528 Caenorhabditis elegans Lowers ROS levels Mito, ETC ROS, CLK-1/COQ7 SmallMolecule \ ROS, CLK-1/COQ7: Nucleus, ROS metabolic genes Mitochondrial homeostasis Monaghan et al. (2015). DOI: 10.1038/ncb3170 https://www.ncbi.nlm.nih.gov/pubmed/25961505
MC529 Caenorhabditis elegans Increased ROS levels Mito, ETC ROS SmallMolecule \ ROS: Nucleus, UPRmt UPRmt(Unfolded Protein Response), Mitochondrial Stress Signaling Monaghan et al. (2015). DOI: 10.1038/ncb3170 https://www.ncbi.nlm.nih.gov/pubmed/25961505
MC530 Homo sapiens Cellular Stress Mito resident protein(Matrix) HSP60 Protein LOX-1 LOX1 Inflammation Zhang et al. (2012). DOI: 10.1016/j.neuint.2012.07.019 https://www.ncbi.nlm.nih.gov/pubmed/22847064
MC531 Homo sapiens Cellular Stress Mito resident protein(Matrix) HSP60 Protein TLR4 Immune Immune Juwono et al. (2016). DOI: 10.1155/2016/8017571 https://www.ncbi.nlm.nih.gov/pubmed/27478851
MC532 Homo sapiens Cellular Stress Mito resident protein(Matrix) HSP60 Protein TLR2 Beta-islet cells Immune Juwono et al. (2016). DOI: 10.1155/2016/8017571 https://www.ncbi.nlm.nih.gov/pubmed/27478851
MC533 Homo sapiens \ Mito, Steroidogenesis Testosterone Steroid Hormone Androgen receptor \ Endocrine, Reproductive Physiology Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC534 Homo sapiens \ Mito, Steroidogenesis Estrogens Steroid Hormone Estrogen (ER) \ Endocrine, Reproductive Physiology Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC535 Homo sapiens \ Mito, Steroidogenesis Progestins Steroid Hormone nuclear progesterone receptor(nPR) Nuclear Endocrine, Reproductive Physiology Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC536 Homo sapiens \ Mito, Steroidogenesis Glucocorticoids Steroid Hormone Glucocorticoids (GC) \ Endocrine, Metabolic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC537 Homo sapiens \ Mito, Steroidogenesis Mineralocorticoids Steroid Hormone Mineralocorticoid receptor \ Endocrine, Metabolic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC538 Homo sapiens \ Mito(neuronal), Steroidogenesis Neurosteroids Steroid Hormone Gamma amino-butyric acid Type A (GABAA) receptors \ Endocrine, Metabolic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC539 Homo sapiens Ca2+, ATP Mito. IMS PTP Cyt c Protein \ ATF-4 Cell death, Mitochondrial Stress Signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC540 Homo sapiens Apoptotic Mito. IMS AIF Protein \ \ Cell death, Apoptosis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC541 Homo sapiens Apoptotic Mito. IMS EndoG Protein \ \ Cell death Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC542 Homo sapiens Apoptosis (MOMP) Mito MOMP SMAC Protein \ \ Cell death Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC543 Homo sapiens Apoptosis (MOMP) Mito MOMP Diablo Protein \ \ Cell death Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC544 Homo sapiens Mitochondrial OxPhos is impaired Mito, Glycolysis Lactate Metabolite \ lactylation PTMs of histones (and other proteins) Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC545 Homo sapiens \ Mito, OMM catabolism Dopamine SmallMolecule.Neurotransmitter \ Dopaminylation PTMs of histones (and other proteins) Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC546 Homo sapiens Low carbohydrate conditions Mito, keton body Beta-hydroxybutyrate Metabolite \ Beta-hydroxybutyration PTMs of histones (and other proteins) Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC547 Homo sapiens \ Mito TCA enzyme Fumarate hydratase Protein.Enzyme \ Electron flux through the OxPhos system Regulate the levels of TCA cycle metabolites succinate and fumarate Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC548 Homo sapiens \ Mito TCA enzyme Succinate dehydrogenase Protein.Enzyme \ Electron flux through the OxPhos system Regulate the levels of TCA cycle metabolites succinate and fumarate Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC549 Homo sapiens \ Mito TCA cycle metabolite aconitate Itaconate Metabolite \ Inhibiting succinate dehydrogenase/NF-kB signaling Intramitochondrial enzyme, transcription factors Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC550 Homo sapiens \ Mito TCA 2-HG Metabolite \ \ Metabolic signal Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC551 Homo sapiens Stress Mito. Inner Membrane IMM cardiolipin Membrane.Lipid \ Translocating to the OMM Cell signaling events, mitophagy, apoptotic signaling Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC552 Homo sapiens \ Mito. Matrix (as electron carrier in ETC) NADH, NAD+ Metabolite \ \ Metabolic signal Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC553 Homo sapiens \ Mito, Carrier proteins on the IMM Citrate carrier Protein \ Regulate export of acetyl-CoA, Drive histone acetylation levels Chromatin accessibility, stem cell differentiation Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC554 Homo sapiens Oxygen tension, DpH+DJm, and ATP demand Mito TCA Succinate Metabolite sucnr1 \ Signal extracellularly and systemically, o regulate inflammatory processes Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC555 Homo sapiens Oxygen tension, DpH+DJm, and ATP demand Mito TCA Succinate Metabolite MCT1 Imported via the monocarboxylate transporter 1 (MCT1) Metabolic Homeostasis Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC556 Homo sapiens \ Mito, Energy/Precursor supply melatonin Hormone.Amino Acid-Derived \ Automitocrine, cellautonomous, paracrine manner Cells/neurons, systemically via the bloodstream Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC557 Homo sapiens \ Mito, ETC H2O2 SmallMolecule \ \ Metabolic signal Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC558 Homo sapiens \ Mitochondria Bioenergetic state Physicochemical State Signals \ \ Metabolic signal Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC559 Homo sapiens Cellular Stress Mito resident protein(Matrix) HSP60 Protein LOX1 \ Systemic signals Picard et al. (2022). DOI: 10.1016/j.cmet.2022.10.008 https://www.ncbi.nlm.nih.gov/pubmed/36323233
MC560 Saccharomyces cerevisiae Oxygen stress, aging Mito, ETC ROS SmallMolecule \ Ras2, ROS, Yca1, apoptosis Cell death Madeo et al. (2002). DOI: 10.1016/S1097-2765(02)00501-4 https://www.ncbi.nlm.nih.gov/pubmed/11983181
MC561 Saccharomyces cerevisiae Osmolarity, Nutrient Mito. OM ATG32 Protein \ Sln1, Ssk1, Pbs2, Hog1, CK2, ATG32, Mitophagy Mitophagy, autophagy Mao et al. (2011). DOI: 10.1083/jcb.201102092 https://www.ncbi.nlm.nih.gov/pubmed/21576396
MC562 Saccharomyces cerevisiae Nutrient Mitophagy Atg11 Protein \ Ras2, pka, ATG1, ATG2, ATG9, ATG11 Autophagy Toda et al. (1987). DOI: 10.1016/0092-8674(87)90223-6 https://www.ncbi.nlm.nih.gov/pubmed/22847064
MC563 Saccharomyces cerevisiae Oxygen stress, aging Mito, ETC ROS SmallMolecule \ Gpr1, Ras2, PKA, RIM15, Gis1, Nuclear, SOD2, HSP Antioxidant response, Autophagy Chevtzoff et al. (2010). DOI: 10.1074/jbc.M109.019570 https://www.ncbi.nlm.nih.gov/pubmed/19897478
MC564 Saccharomyces cerevisiae \ Mito. Matrix, beta-Oxidation Oleicacid Lipid.FattyAcid Bcl-2-like protein 11(Homo sapiens) \ Interspecies signals Broad Institute. (2010). PubChem AID: 2765 https://pubchem.ncbi.nlm.nih.gov/bioassay/2765
MC565 Saccharomyces cerevisiae \ Mito. Matrix, beta-Oxidation Linoleic Acid Lipid.FattyAcid Fatty acid-binding protein 5 \ Metabolic signal Armstrong et al. (2014). DOI: 10.1074/jbc.M113.514646 https://www.ncbi.nlm.nih.gov/pubmed/24692551
MC566 Saccharomyces cerevisiae \ Mito. Matrix, beta-Oxidation Palmitoleic acid Lipid.FattyAcid Fatty acid-binding protein 5 \ Metabolic signal Armstrong et al. (2014). DOI: 10.1074/jbc.M113.514646 https://www.ncbi.nlm.nih.gov/pubmed/24692551
MC567 Saccharomyces cerevisiae \ Mito. Matrix, beta-Oxidation Palmitic acid Lipid.FattyAcid Fatty acid-binding protein 5 \ Metabolic signal Armstrong et al. (2014). DOI: 10.1074/jbc.M113.514646 https://www.ncbi.nlm.nih.gov/pubmed/24692551
MC568 Saccharomyces cerevisiae \ Mito. Matrix Nicotinamide(NAM) Metabolite Poly [ADP-ribose] polymerase 1 \ Metabolic signal Eltze et al. (2008). DOI: 10.1124/mol.108.048751 https://www.ncbi.nlm.nih.gov/pubmed/18809672
MC569 Saccharomyces cerevisiae \ Mito. Matrix Nicotinamide(NAM) Metabolite Poly [ADP-ribose] polymerase 2 \ Metabolic signal Eltze et al. (2008). DOI: 10.1124/mol.108.048751 https://www.ncbi.nlm.nih.gov/pubmed/18809672
MC570 Saccharomyces cerevisiae \ Mito. Matrix Nicotinamide(NAM) Metabolite NAD-dependent protein deacylase sirtuin-6 \ Metabolic signal Bolivar et al. (2017). DOI: 10.1002/cbic.201600655 https://www.ncbi.nlm.nih.gov/pubmed/28222243
MC571 Saccharomyces cerevisiae \ Mito. Matrix, One-carbon metabolism, Purine synthesis Adenine Metabolite Heat shock protein HSP 90-beta(Homo sapiens) \ Interspecies signals Brough et al. (2009). DOI: 10.1021/jm900357y https://www.ncbi.nlm.nih.gov/pubmed/19610616
MC572 Saccharomyces cerevisiae \ Mito. Matrix, One-carbon metabolism, Purine synthesis Adenine Metabolite Xanthine dehydrogenase/oxidase(Homo sapiens) \ Interspecies signals Tamta et al. (2005). DOI: 10.1080/14756360500112326 https://www.ncbi.nlm.nih.gov/pubmed/16206825
MC573 Saccharomyces cerevisiae \ Mito, Arginine metabolism L-Arginine Metabolite N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Homo sapiens) \ Interspecies signals Wang et al. (2009). DOI: 10.1021/bi9007098 https://www.ncbi.nlm.nih.gov/pubmed/19663506
MC574 Saccharomyces cerevisiae \ Mito, Arginine metabolism L-Arginine Metabolite Nitric oxide synthase, brain(Homo sapiens) \ Interspecies signals Wang et al. (2009). DOI: 10.1021/bi9007098 https://www.ncbi.nlm.nih.gov/pubmed/19663506
MC575 Homo sapiens/Mus musculus Aging (age-associated NAD+ decline) Adipose tissue (encapsulated in extracellular vesicles) eNAMPT (extracellular NAMPT) Protein.Enzyme \ NAD+ biosynthesis (via EV internalization), SIRT1 activation, LKB1-AMPK phosphorylation Promote hypothalamic NAD+ biosynthesis, enhance thermogenesis, suppress Npy/Agrp expression, activate Ppargc1a/Ox2r Yoshioka et al. (2025). DOI: 10.1038/s41514-025-00297-y https://www.ncbi.nlm.nih.gov/pubmed/41285826
MC576 Caenorhabditis elegans Neuronal Mitochondrial Stress (e.g., ETC inhibition, protein aggregation) ADF Sensory Neurons Ca2+ Oscillations SmallMolecule TMBIM-2 / MCA-3 complex Calcium Homeostasis Generates spatiotemporal Ca2+ dynamics to facilitate neurotransmission Li et al. (2025). DOI: 10.1083/jcb.202408050 https://www.ncbi.nlm.nih.gov/pubmed/40100072
MC577 Caenorhabditis elegans Neuronal Mitochondrial Stress ADF Sensory Neurons Serotonin (5-HT) SmallMolecule.Neurotransmitter (Putative 5-HT receptor in intestine, not specified in paper) Neurotransmission Activates the cell non-autonomous UPRmt in the intestine Li et al. (2025). DOI: 10.1083/jcb.202408050 https://www.ncbi.nlm.nih.gov/pubmed/40100072
MC578 Caenorhabditis elegans Neuronal Mitochondrial Stress ADF Sensory Neurons, Intestine UPRmt Activation (DVE-1, ATFS-1) Protein (Intestinal UPRmt machinery) Mitochondrial Unfolded Protein Response Systemic metabolic adaptation, stress resilience Li et al. (2025). DOI: 10.1083/jcb.202408050 https://www.ncbi.nlm.nih.gov/pubmed/40100072
MC579 Caenorhabditis elegans Aging, Pathogen Exposure Nervous System TMBIM-2 Expression Level Protein \ Aversive Learning Behavior Cognitive function, pathogen avoidance Li et al. (2025). DOI: 10.1083/jcb.202408050 https://www.ncbi.nlm.nih.gov/pubmed/40100072
MC580 Caenorhabditis elegans Aging Nervous System TMBIM-2 Expression Level Protein \ Lifespan Regulation Promotes longevity and healthspan Li et al. (2025). DOI: 10.1083/jcb.202408050 https://www.ncbi.nlm.nih.gov/pubmed/40100072
Note: A "\" indicates that data is missing or unavailable.